(4S,5S)-2,2-dimethyl-alpha,alpha,alpha',alpha'-tetra-1-naphthalenyl-1,3-dioxolane-4,5-dimethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4S,5S)-2,2-dimethyl-alpha,alpha,alpha',alpha'-tetra-1-naphthalenyl-1,3-dioxolane-4,5-dimethanol
• 英文别名: [5-[hydroxy(dinaphthalen-1-yl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-dinaphthalen-1-ylmethanol
• 化学式: C₄₇H₃₈O₄
• 分子量: 666.8
• InChiKey: WTZVNZRNIOJACO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHOD FOR MANUFACTURING OPTICALLY ACTIVE MENTHOL
  申请人：Tsuda Toshiro

  公开号：US20130253228A1

  公开（公告）日：2013-09-26

  An object of the present invention is to provide a method for manufacturing an optically active menthol having fewer steps, which generates less environmentally polluting waste because a catalytic reaction is involved in all of the steps, and is capable of saving a production cost. The present invention relates to a method for manufacturing an optically active menthol, including the following steps: A-1) asymmetrically hydrogenating at least one of geranial and neral to thereby obtain an optically active citronellal, B-1) conducting a ring-closure reaction of the optically active citronellal in the presence of an acid catalyst to thereby obtain an optically active isopulegol, and C-1) hydrogenating the optically active isopulegol to thereby obtain an optically active menthol.

  本发明的目的是提供一种制造具有较少步骤的光学活性薄荷醇的方法，因为所有步骤都涉及催化反应，所以产生的环境污染废物较少，并且能够节省生产成本。本发明涉及一种制造光学活性薄荷醇的方法，包括以下步骤：A-1）不对称地氢化至少一种香叶醛和柠檬醛以获得光学活性柠檬醛，B-1）在酸催化剂存在下对光学活性柠檬醛进行环闭合反应，从而获得光学活性异薄荷醇，以及C-1）对光学活性异薄荷醇进行氢化以获得光学活性薄荷醇。
• ORGANOALUMINUM COMPOUND
  申请人：ITOH Hisanori

  公开号：US20110295031A1

  公开（公告）日：2011-12-01

  A catalyst for obtaining isopulegol of high diastereoselectivity by highly selective cyclization reaction of citronellal is provided. The present invention relates to an organoaluminum compound obtained by reacting at least one organoaluminumoxy compound selected from the group consisting of chain aluminoxanes, cyclic aluminoxanes and bis(dialkylaluminumoxy)alkylboranes, with at least one hydroxy compound selected from the group consisting of diarylphenols, bis(diarylphenol) compounds, biaryldiols, dimethanols and silanols.

  本发明提供了一种催化剂，用于通过高度选择性的环化反应从香茅醛中获得高对映选择性的异莰醇。本发明涉及通过将链状铝氧烷、环状铝氧烷和双(二烷基氧基)烷基硼烷等组中至少一种有机铝氧化合物与二苯基酚、双(二苯基酚)化合物、联苯二醇、二甲醇和硅烷等组中至少一种羟基化合物反应而得到的有机铝化合物。
• Catalytic halogenation of activated methylene and methine compound
  申请人：Solvias AG

  公开号：EP1151980A1

  公开（公告）日：2001-11-07

  A process for the halogenation of activated methylene and methine compounds with at least equimolar amounts of an electrophilic halogenation reagent, which comprises reacting said activated methylene and methine compounds in the presence of catalytic amounts of a titanium compound of the formula I or of a titanium compound of the formula IIR1TiX1X2X3R2R3TiX1X2 in which R1 is chlorine, bromine or iodine, a substituted or unsubstituted cyclopentadienyl or indenyl, and X1, X2 and X3 are, independently of one another, chlorine, bromine or iodine, or X1, X2 and X3 are an organic sulfonate group where R1 is a substituted or unsubstituted cyclopentadienyl or indenyl; R2 and R3 are a substituted or unsubstituted cyclopentadienyl or indenyl, R2 and R3 together are a substituted or unsubstituted and bridged or unbridged biscyclopentadienyl or bisindenyl, or R2 and R3 together are a substituted or unsubstituted 1,3-, 1,4- or 1,5-diolate, and X1 and X2 are, independently of one another, chlorine, bromine or iodine or an organic sulfonate group. If the diolate is enantiopure, the process is enantioselective on use of racemic activated methine compounds.

  一种用至少等摩尔量的亲电卤化试剂卤化活化亚甲基和亚甲基化合物的工艺，该工艺包括在催化量的式 I 钛化合物或式 IIR1TiX1X2X3R2R3TiX1X2 的钛化合物存在下使所述活化亚甲基和亚甲基化合物反应，其中 R1 是氯、溴或碘、取代或未取代的环戊二烯基或茚基，X1、X2 和 X3 相互独立地是氯、溴或碘，或 X1、X2 和 X3 是有机磺酸盐基团，其中 R1 是取代或未取代的环戊二烯基或茚基； R2 和 R3 是取代或未取代的环戊二烯基或茚基，R2 和 R3 合在一起是取代或未取代且桥接或未桥接的双环戊二烯基或双茚基，或 R2 和 R3 合在一起是取代或未取代的 1,3-、1,4- 或 1,5 二酸酯，且 X1 和 X2 相互独立地是氯、溴或碘或有机磺酸盐基团。 如果二元酸盐是对映体纯品，则该工艺在使用外消旋活化甲烷化合物时具有对映体选择性。
• Organoaluminium compounds and their use as catalysts in the selective cyclisation of citronellal to isopulegol
  申请人：Takasago International Corporation

  公开号：EP2390001A1

  公开（公告）日：2011-11-30

  A catalyst for obtaining isopulegol of high diastereoselectivity by highly selective cyclization reaction of citronellal is provided. The present invention relates to an organoaluminum compound obtained by reacting at least one organoaluminumoxy compound selected from the group consisting of chain aluminoxanes, cyclic aluminoxanes and bis(dialkylaluminumoxy)alkylboranes, with at least one hydroxy compound selected from the group consisting of diarylphenols, bis(diarylphenol) compounds, biaryldiols, dimethanols and silanols.

  本发明提供了一种通过香茅醛的高选择性环化反应获得高非对映选择性异普来醇的催化剂。本发明涉及一种有机铝化合物，该化合物是由至少一种选自链状铝氧烷、环状铝氧烷和双(二烷基铝氧)烷基硼烷的有机铝氧化合物与至少一种选自二芳基苯酚、双(二芳基苯酚)化合物、双芳基二醇、二甲醇和硅烷醇的羟基化合物反应得到的。
• US6025503A
  申请人：——

  公开号：US6025503A

  公开（公告）日：2000-02-15