1-(1-adamantyl)piperidine | 22947-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-adamantyl)piperidine
• 英文别名: Adamantane, 1-(1-piperazinyl)
• CAS: 22947-47-3
• 化学式: C₁₅H₂₅N
• 分子量: 219.37
• InChiKey: BIGXHKHDJAZATA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  哌啶 、 1,3-脱氢金刚烷 反应 6.0h， 以76%的产率得到1-(1-adamantyl)piperidine
  参考文献：
  名称：

  Adamantylation of saturated nitrogen-containing heterocycles

  摘要：

  DOI：

  10.1134/s1070428014030270

文献信息

• [EN] ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPLEXES ORGANOMÉTALLIQUES DE TRANSITION POUR LE TRAITEMENT DES INFECTIONS VIRALES
  申请人：BUSATH DAVID D

  公开号：WO2015192037A1

  公开（公告）日：2015-12-17

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.

  有机过渡金属配合物具有抗流感病毒的抑制活性，包括S3 IN突变体。有机过渡金属配合物包括过渡金属和至少一种基于M2质子通道阻滞剂结构的配体。这些化合物和药物组合物对治疗流感病毒等病毒有用。
• Polyhydroxybenzyloxypropanolamines
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0373591A2

  公开（公告）日：1990-06-20

  Compounds of the present invention, are represented by the general formula wherein R₁ group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, nitro, alkylamino of from 1 to about 6 carbon atoms, hydroxy, hydroxyalkyl of from 1 to about 6 carbon atoms, cyano or arylalkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms R₂, R₃ and R₄ are hydrogen or hydroxyl groups or the combination of either hydrogen or hydroxyl groups; W represents alkylene of from 1 to about 10 carbon atoms; and B represents -NHCOR₅, -NHCONR₅R₆, or -NHCOOR₅ wherein R₅ and R₆ may be the same or different and represent hydrogen, alkyl of from 1 to about 6 carbon atoms, alkoxyalkyl wherein the alkyl groups may be the same or different and contain from 1 to about 6 carbon atoms, cycloalkyl of from 3 to about 8 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 6 carbon atoms, phenyl which may be unsubstituted or substituted with alkyl of 1 to 6 carbon atoms; furanyl, thiophenyl, imidazole, oxazole or indole, aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl unsubstituted or substituted with alkyl of from 1 to about 6 carbon atoms, or R₅ and R₆ may together with N form a pyrrolidine, piperidine, piperazine, morpholine or thiomorpholine ring and except that R₅ is not hydrogen when B is -NHCOOR₅; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorders or in the treatment of glaucoma.

  本发明的化合物由通式表示 其中 R₁ 基团可以是 1 至约 6 个碳原子的烷基、2 至约 6 个碳原子的烯基、2 至约 10 个碳原子的炔基、烷氧基（其中烷基含有 1 至约 6 个碳原子）、卤素、乙酰胺基、氨基、硝基、1 至约 6 个碳原子的烷基氨基、羟基、1 至约 6 个碳原子的羟烷基、氰基或芳基、R₂、R₃ 和 R₄ 是氢或羟基或氢或羟基的组合；W 代表 1 至约 10 个碳原子的亚烷基；B代表-NHCOR₅、-NHCONR₅R₆或-NHCOOR₅，其中R₅和R₆可以相同或不同，代表氢、1至约6个碳原子的烷基、烷氧基烷基，其中烷基可以相同或不同，含有1至约6个碳原子、3-约 8 个碳原子的环烷基、2-约 6 个碳原子的烯基、2-约 6 个碳原子的炔基、未取代或被 1-6 个碳原子的烷基取代的苯基；呋喃基、噻吩基、咪唑基、噁唑基或吲哚基、芳烷基，其中烷基含有 1 至约 6 个碳原子，芳基代表未取代的苯基或被 1 至约 6 个碳原子的烷基取代的苯基、或 R₅ 和 R₆ 可与 N 一起形成吡咯烷、哌啶、哌嗪、吗啉或硫代吗啉环，但当 B 为 -NHCOOR₅ 时，R₅ 不是氢；或其药学上可接受的盐。这些化合物可用于治疗或预防心脏疾病或治疗青光眼。
• ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：BUSATH David D.

  公开号：US20170128489A1

  公开（公告）日：2017-05-11

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.