ethyl 3-oxo-(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cycloheptene]-2-carboxylate | 1262803-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: ethyl 3-oxo-(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cycloheptene]-2-carboxylate
• 英文别名: ethyl (2S)-5-oxospiro[cyclopentane-2,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-carboxylate
• CAS: 1262803-06-4
• 化学式: C₂₂H₂₂O₃
• 分子量: 334.415
• InChiKey: NWUCKFMQOSRRBG-LWMIZPGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 3-oxo-(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cycloheptene]-2-carboxylate 在 4-二甲氨基吡啶 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以83%的产率得到(+)-(1S)-5',11'-dihydro-3H-spiro[cyclopentane-1,10'-dibenzo-[a,d]cyclohepten]-3-one
  参考文献：
  名称：

  Asymmetric route to spirotetracyclic (1S)-5′,11′-dihydro-3H-spiro[cyclopentane-1,10′-dibenzo[a,d]cyclohepten]-3-one derivatives

  摘要：

  A new synthetic pathway to the final compound 1-[(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cyclohepten]-3-yl]-3-azetidinecarboxylic acid (1) was set up. The two preparative chiral HPLC separations needed in the first route were successfully avoided and replaced by two diastereomeric crystallizations of intermediate compounds 5 and 10. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.039
• 作为产物：
  描述：

  ethyl 2-diazo-3-oxo-5-[(9S)-9-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl]pentanoate 在 rhodium(II) acetate dimer 作用下， 以 二氯甲烷 为溶剂， 反应 3.5h， 以46.6%的产率得到ethyl 3-oxo-(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cycloheptene]-2-carboxylate
  参考文献：
  名称：

  Asymmetric route to spirotetracyclic (1S)-5′,11′-dihydro-3H-spiro[cyclopentane-1,10′-dibenzo[a,d]cyclohepten]-3-one derivatives

  摘要：

  A new synthetic pathway to the final compound 1-[(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cyclohepten]-3-yl]-3-azetidinecarboxylic acid (1) was set up. The two preparative chiral HPLC separations needed in the first route were successfully avoided and replaced by two diastereomeric crystallizations of intermediate compounds 5 and 10. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.039

文献信息

• Asymmetric route to spirotetracyclic (1S)-5′,11′-dihydro-3H-spiro[cyclopentane-1,10′-dibenzo[a,d]cyclohepten]-3-one derivatives
  作者：Massimo Gianotti、Daniele Andreotti、Davide Casotto、Mario Mattioli、Anna Mingardi、Francesca Pavone、Roberto Profeta、Filippo Valente

  DOI：10.1016/j.tetlet.2010.11.039

  日期：2011.1

  A new synthetic pathway to the final compound 1-[(1S)-5',11'-dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]cyclohepten]-3-yl]-3-azetidinecarboxylic acid (1) was set up. The two preparative chiral HPLC separations needed in the first route were successfully avoided and replaced by two diastereomeric crystallizations of intermediate compounds 5 and 10. (C) 2010 Elsevier Ltd. All rights reserved.