N-Tetracosanoyl-DL-sphingosin | 869501-31-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-Tetracosanoyl-DL-sphingosin
• 英文别名: N-tetracosanoyl-sphingosine；N-[(3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]tetracosanamide；N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide
• CAS: 869501-31-5
• 化学式: C₄₂H₈₃NO₃
• 分子量: 650.126
• InChiKey: ZJVVOYPTFQEGPH-MHAUTQJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.2
• 重原子数：
  46
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Tetracosanoyl-DL-sphingosin 、 氯化溴 生成 [(E)-3-benzoyloxy-2-(tetracosanoylamino)octadec-4-enyl] benzoate
  参考文献：
  名称：

  SNADA, SABUROU;UCHIDA, YOSHIKAZU;ANRAKI, YORIKO;IZAWA, ATSUKO;IWAMORI, MA+, J. CHROMATOGR., 400,(1987) 223-231

  摘要：

  DOI：

文献信息

• COMPOSITION FOR EXTERNAL APPLICATION CONTAINING A CERAMIDE, A DERIVATIVE THEREOF AND AN EXTRACT OF HIBISCI CORTEX
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20200179260A1

  公开（公告）日：2020-06-11

  The present disclosure relates to an external-use skin preparation composition containing a natural ceramide, a ceramide derivative, and a Hibisci cortex extract, and more specifically, the present disclosure relates to an external-use skin preparation composition containing these ingredients, thereby being effective for enhancing skin moisturizing ability, reducing skin wrinkles, and enhancing elasticity. In addition, the present disclosure relates to use of the composition, and a method for improving skin moisturization, reducing skin wrinkles, and/or improving skin elasticity by using the composition.

  本公开涉及一种含有天然酯化酰胺、酰胺衍生物和芙蓉皮提取物的外用皮肤制剂组合物，更具体地说，本公开涉及一种含有这些成分的外用皮肤制剂组合物，因此对于增强皮肤保湿能力、减少皮肤皱纹和增强弹性具有有效作用。此外，本公开还涉及使用该组合物的方法以及通过使用该组合物改善皮肤保湿、减少皮肤皱纹和/或改善皮肤弹性的方法。
• Method for producing glycoconjugates
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0897014A2

  公开（公告）日：1999-02-17

  A method for producing glycoconjugate, which comprises the steps of: (i) binding a sugar residue to the side chain of a water-soluble polymer via a linker having a selectively cleavable linkage to give a primer, and bringing said primer into contact with an immobilized glycosyltransferase in the presence of a sugar nucleotide, to transfer a sugar residue of said sugar nucleotide to the sugar residue of said primer, (ii) elongating a sugar chain by transfer of plural sugar residues by repeating the step (i) at least once, (iii) removing, where necessary, a by-produced nucleotide or an unreacted sugar nucleotide, and (iv) repeating the steps (i)-(iii) where necessary and releasing the glycoconjugate by selectively cleaving the cleavable linkage in the linker, from the above-mentioned primer connecting the sugar chain elongated by the transfer of plural sugar residues, and a method for producing a sphingoglycolipid.

  一种生产糖共轭物的方法，包括以下步骤 (i) 通过具有选择性可裂解连接的连接体，将糖残基与水溶性聚合物的侧链结合，得到引物，并在糖核苷酸存在的情况下，使所述引物与固定的糖基转移酶接触，将所述糖核苷酸的糖残基转移到所述引物的糖残基上、 (ii) 重复步骤(i)至少一次，通过转移多个糖残基拉长糖链、 (iii) 必要时去除副产核苷酸或未反应的糖核苷酸，以及 (iv) 必要时重复步骤(i)-(iii)，通过选择性地裂解连接体中的可裂解连接，从上述连接通过转移多个糖残基拉长的糖链的引物中释放出糖共轭物、 以及一种生产鞘氨醇糖脂的方法。
• OXIDATIVE HAIR DYE COMPOSITION
  申请人：Kao Corporation

  公开号：EP2151232A1

  公开（公告）日：2010-02-10

  Provided is an oxidative hair dye composition containing Components (A) to (D): (A) an iso-fatty acid or an anteiso-fatty acid having from 19 to 30 carbon atoms, or a salt thereof; (B) a polymer or a copolymer of a diallyl quaternary ammonium salt; (C) an oxidation dye; and (D) an alkali agent.

  本发明提供了一种氧化性染发剂组合物，其中含有组分(A)至(D)： (A) 具有 19 至 30 个碳原子的异脂肪酸或反异脂肪酸，或其盐； (B) 二烯丙基季铵盐的聚合物或共聚物； (C) 氧化染料；及 (D) 碱剂。
• TWO-COMPONENT OXIDATIVE HAIR DYE COMPOSITION
  申请人：Kao Corporation

  公开号：EP2151233A1

  公开（公告）日：2010-02-10

  Provided is a two-part oxidative hair dye composition having a first agent containing an alkali agent and an oxidation dye intermediate or a direct dye and a second agent containing an oxidizing agent, wherein at least one of the first and second agents contains both of Components (A) and (B): (A) an iso-fatty acid or an anteiso-fatty acid having from 19 to 30 carbon atoms, or a salt thereof, and (B) a quaternary cationic surfactant.

  本发明提供了一种双组分氧化染发组合物，该组合物具有含有碱剂和氧化染料中间体或直接染料的第一剂和含有氧化剂的第二剂，其中第一剂和第二剂中至少有一种含有组分(A)和(B)： (A) 具有 19 至 30 个碳原子的异脂肪酸或反异脂肪酸，或其盐，和 (B) 季阳离子表面活性剂。
• COSMETIC
  申请人：Kao Corporation

  公开号：EP2662071A1

  公开（公告）日：2013-11-13

  A cosmetic comprising the following components (A), (B), (C) and (D): (A) 0.001 to 50 % by weight of an organic acid represented by a general formula (1), wherein R1 denotes a residue derived from a natural sterin having one hydroxy group or a hydrogenated product thereof, or a residue derived from bile acid in which the hydroxyl hydrogen atom is removed; R2 denotes a divalent hydrocarbon group having 1 to 24 carbon atoms; and M denotes a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, alkanolammonium having 2 to 9 carbon atoms in total, alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, a pyridinium substituted with an alkyl group or an alkenyl group having 1 to 18 carbon atoms, or a basic amino acid; (B) 0.001 to 20% by weight of a base; (C) 0.0001 to 50% by weight of a ceramide; and (D) water, and comprising, as a component (E), an acid other than the component (A) in a content satisfying a relationship: 0 ≤ (E)/(A) < 0.2, and having pH of 6 to 11.

  一种化妆品，由以下成分组成(A)、(B)、(C)和(D)： (A) 0.001-50%（按重量计）由通式（1）表示的有机酸，其中 R1 表示从具有一个羟基的天然固醇提取的残留物或其氢化产物，或从胆汁酸提取的残留物，其中的羟基氢原子被去除；R2 表示具有 1-24 个碳原子的二价烃基；M 表示氢原子、碱金属、碱土金属、铵、共 2 至 9 个碳原子的烷醇铵、共 1 至 22 个碳原子的烷基铵或烯基 铵、被 1 至 18 个碳原子的烷基或烯基取代的吡啶鎓或碱性氨基酸； (B) 0.001 至 20%（重量百分比）的碱； (C) 0.0001 至 50%（重量百分比）的神经酰胺；以及 (D) 水、 作为成分(E)，还包括成分(A)以外的一种酸，其含量满足以下关系：0 ≤ (E)/(A) < 0.2，pH 值为 6 至 11。