1-(4-methylpiperazino)-2-(1-naphthyloxy)-1-ethanone | 856437-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-methylpiperazino)-2-(1-naphthyloxy)-1-ethanone
• 英文别名: 1-(4-Methylpiperazin-1-yl)-2-naphthalen-1-yloxyethanone
• CAS: 856437-05-3
• 化学式: C₁₇H₂₀N₂O₂
• 分子量: 284.358
• InChiKey: JQHDFUFSPLWSCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  萘酚 在 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 丁酮 为溶剂， 反应 5.0h， 生成 1-(4-methylpiperazino)-2-(1-naphthyloxy)-1-ethanone
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of some new naphthol derived aryloxy derivatives as cognition enhancers

  摘要：

  The present research was designed to describe the synthesis of a series of some 1-naphthol derivatives with their antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds were characterized by spectroscopic techniques, elemental analysis and were screened for their efficacy as cognition enhancers by elevated plus maze test and acetylcholinestrase inhibitory assay. Compound 7a was found to be the most potent in reversing the amnesia and in inhibiting the acetylcholinesterase.

  DOI：

  10.1007/s00044-011-9686-1

文献信息

• Synthesis and pharmacological evaluation of some new naphthol derived aryloxy derivatives as cognition enhancers
  作者：Poonam Piplani、Ruchi Malik、Bhavneet Kaur、Anuradha Kaplish

  DOI：10.1007/s00044-011-9686-1

  日期：2012.8

  The present research was designed to describe the synthesis of a series of some 1-naphthol derivatives with their antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds were characterized by spectroscopic techniques, elemental analysis and were screened for their efficacy as cognition enhancers by elevated plus maze test and acetylcholinestrase inhibitory assay. Compound 7a was found to be the most potent in reversing the amnesia and in inhibiting the acetylcholinesterase.