N-methyl-N-tert-butyl-1-naphthylamine | 110014-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-methyl-N-tert-butyl-1-naphthylamine
• 英文别名: N-tert-butyl-N-methylnaphthalen-1-amine
• CAS: 110014-43-2
• 化学式: C₁₅H₁₉N
• 分子量: 213.323
• InChiKey: ORYOEEQBXXOSQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基-叔丁基胺 、 1-溴代萘 在 正丁基锂 作用下， 生成 N-methyl-N-tert-butyl-1-naphthylamine
  参考文献：
  名称：

  Conformational studies by dynamic NMR. 32. Enantiomerization of chiral conformers in hindered naphthylamines and naphthyl nitroxides

  摘要：

  DOI：

  10.1021/jo00230a013

文献信息

• NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Yoshida Tomohiro

  公开号：US20100228026A1

  公开（公告）日：2010-09-09

  The invention provides a sulfonyl malonamide derivative, or a pharmacologically acceptable salt thereof or a solvate thereof, that has therapeutic and/or preventive effect(s) on various diseases due to its agonist action at AT 2 receptor, and is useful as a pharmaceutical agent for the treatment and/or prevention of diseases involving the renin-angiotensin-aldosterone system (RAAS).

  该发明提供了一种磺酰基马隆酰胺衍生物，或其药理学上可接受的盐或溶剂，由于其在AT2受体上的激动剂作用，对各种疾病具有治疗和/或预防作用，并且作为用于治疗和/或预防涉及肾素-血管紧张素-醛固酮系统（RAAS）疾病的药物剂形具有用处。
• MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS
  申请人：NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

  公开号：US20170014419A1

  公开（公告）日：2017-01-19

  Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.
• US8461209B2
  申请人：——

  公开号：US8461209B2

  公开（公告）日：2013-06-11
• [EN] METHOD FOR DETERMINING AUTHENTICITY AND ADULTERATION OF MARKED PETROLEUM HYDROCARBONS<br/>[FR] PROCÉDÉ PERMETTANT DE DÉTERMINER L'AUTHENTICITÉ ET L'ADULTÉRATION D'HYDROCARBURES PÉTROLIERS MARQUÉS
  申请人：SICPA HOLDING SA

  公开号：WO2021110525A1

  公开（公告）日：2021-06-10

  The present invention provides a method for determining the authenticity of a petroleum hydrocarbon allegedly comprising at least one specific chemical marker, as well as a method for determining adulteration of a petroleum hydrocarbon marked with at least one specific chemical marker. The methods claimed and described herein rely upon the use of specific chemical markers in combination with laser ionization at a wavelength of between about 300 nm and about 370 nm coupled with ion mobility spectrometry or with mass spectrometry.
• Conformational studies by dynamic NMR. 32. Enantiomerization of chiral conformers in hindered naphthylamines and naphthyl nitroxides
  作者：D. Casarini、L. Lunazzi、G. Placucci、D. Macciantelli

  DOI：10.1021/jo00230a013

  日期：1987.10