4-[4-Carboxy-3-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoyl]-2-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[4-Carboxy-3-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoyl]-2-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoic acid
• 英文别名: 4-[4-carboxy-3-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoyl]-2-[[hydroxy(naphthalen-1-yl)methylidene]amino]benzoic acid
• 化学式: C₃₇H₂₄N₂O₇
• 分子量: 608.6
• InChiKey: RMHMFJFBVDQSGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  46
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Nuclease inhibitor cocktail
  申请人：Latham J. Gary

  公开号：US20050014169A1

  公开（公告）日：2005-01-20

  Methods and compositions for inhibiting and/or inactivating nucleases by using nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease inhibitors.

  本研究提供了使用核酸酶抑制剂抑制和/或灭活核酸酶的方法和组合物。核酸酶抑制剂包括抗核酸酶抗体和非抗体核酸酶抑制剂。
• Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
  申请人：Shapiro Robert

  公开号：US20070032418A1

  公开（公告）日：2007-02-08

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• US7264932B2
  申请人：——

  公开号：US7264932B2

  公开（公告）日：2007-09-04
• [EN] SMALL-MOLECULE INHIBITORS OF ANGIOGENIN AND RNASES AND IN VIVO AND IN VITRO METHODS OF USING SAME<br/>[FR] INHIBITEURS D'ANGIOGENINE ET DE RNASES A PETITES MOLECULES ET LEURS PROCEDES D'UTILISATION IN VIVO ET IN VITRO
  申请人：AMBION INC

  公开号：WO2004076640A2

  公开（公告）日：2004-09-10

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• [EN] IMPROVED NUCLEASE INHIBITOR COCKTAIL<br/>[FR] COCKTAIL AMELIORE DESTINE A INHIBER LES NUCLEASES
  申请人：AMBION INC

  公开号：WO2005083081A1

  公开（公告）日：2005-09-09

  Methods and compositions for inhibiting and/or inactivating nucleases by using nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease inhibitors.