2-chloro-3-amino-1,4-naphthoquinone-6-sulfonamide | 104411-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-chloro-3-amino-1,4-naphthoquinone-6-sulfonamide
• 英文别名: 7-Amino-6-chloro-5,8-dioxonaphthalene-2-sulfonamide
• CAS: 104411-66-7
• 化学式: C₁₀H₇ClN₂O₄S
• 分子量: 286.696
• InChiKey: ICJBRQPJQVOTDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-dichloro-1,4-naphthoquinone-6-sulfonyl chloride 、 碳酸铵 生成 2-chloro-3-amino-1,4-naphthoquinone-6-sulfonamide
  参考文献：
  名称：

  SHISHKINA, R. P.;MAMATYUK, V. I.;EHKTOVA, L. V.;FOKIN, E. P., IZV. AN CCCP. CEP. XIM., 1985, N 11, 2524-2530

  摘要：

  DOI：

文献信息

• T5 exonuclease-based method to identify DNA topoisomerase inhibitors
  申请人：Leng Fenfei

  公开号：US11268129B1

  公开（公告）日：2022-03-08

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.

  本发明提供了研究DNA拓扑结构和拓扑异构酶的检测方法。这些检测方法利用包含一个或多个发夹结构的环状质粒 DNA 以及 T5 外切酶（T5E）以特定构型消化环状质粒 DNA 的能力。这些检测方法可用于高通量筛选 DNA 回旋酶和 DNA 拓扑异构酶 I 等的抑制剂，以发现抗癌药物和抗生素。
• Reaction of 6-sulfonyl-2,3-dichloro-1,4-naphthaquinones with nucleophilic reagents
  作者：R. P. Shishkina、V. I. Mamatyuk、L. V. �ktova、E. P. Fokin

  DOI：10.1007/bf00956796

  日期：1985.11
• T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS
  申请人：LENG Fenfei

  公开号：US20220119858A1

  公开（公告）日：2022-04-21

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.
• SHISHKINA, R. P.;MAMATYUK, V. I.;EHKTOVA, L. V.;FOKIN, E. P., IZV. AN CCCP. CEP. XIM., 1985, N 11, 2524-2530
  作者：SHISHKINA, R. P.、MAMATYUK, V. I.、EHKTOVA, L. V.、FOKIN, E. P.

  DOI：——

  日期：——