N-(5-羟基-1-萘基)-4-甲基苯磺酰胺 | 54179-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-(5-羟基-1-萘基)-4-甲基苯磺酰胺
• 英文名称: 5-p-Toluolsulfonamido-1-naphthol
• 英文别名: Benzenesulfonamide, N-(5-hydroxy-1-naphthalenyl)-4-methyl-；N-(5-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide
• CAS: 54179-45-2
• 化学式: C₁₇H₁₅NO₃S
• 分子量: 313.377
• InChiKey: CJQANEIQSNYREL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  N-(5-羟基-1-萘基)-4-甲基苯磺酰胺 生成 1-hydroxy-5-[(4-methylphenyl)sulfonylamino]naphthalene-2-carboxylic acid
  参考文献：
  名称：

  KIKUTI, KADZUNORI;YAMAUTI, XIDEHO

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氨基-5-萘酚 生成 N-(5-羟基-1-萘基)-4-甲基苯磺酰胺
  参考文献：
  名称：

  KIKUTI, KADZUNORI;YAMAUTI, XIDEHO

  摘要：

  DOI：

文献信息

• Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair
  作者：Eunhyun Choi、Jiyun Lee、Seahyoung Lee、Byeong-Wook Song、Hyang-Hee Seo、Min-Ji Cha、Soyeon Lim、Chulho Lee、Suk-Won Song、Gyoonhee Han、Ki-Chul Hwang

  DOI：10.1016/j.bmcl.2016.08.069

  日期：2016.10

  The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose-derived MSCs (hASCs). Unlike other chondrogenic

  关节软骨受损的修复是再生医学的长期目标。间充质干细胞（MSCs）的软骨细胞特异性分化可能是修复受损软骨的有效手段。我们确定了磺酰胺作为促进人脂肪来源的MSC（hASCs）的特定软骨分化的试剂的小分子6。与其他由各种定义成分组成的软骨分化培养基不同，在本研究中，仅将化合物6添加到培养基中就足以诱导软骨形成。在动物骨关节炎模型中，小分子6和6经治疗的hASC显示出受损的关节软骨恢复增强。这项工作为小分子诱导的MSC分化提供了新的见识，并为关节软骨损伤提供了潜在的新治疗方法。
• Magenta image-providing phenylazo-naphthyl dyes
  申请人：Eastman Kodak Company

  公开号：US03932381A1

  公开（公告）日：1976-01-13

  Magenta image dye-providing compound having formulas as follows: ##SPC1## Wherein: Car represents a carrier moiety which, as a function of oxidation under alkaline conditions, releases a diffusible dye from said compound; m and q each represent an integer having a value of 0 or 1; X represents a bivalent linking group; R represents hydrogen or alkyl; J represents a bivalent radical selected from sulfonyl or carbonyl; Q represents hydrogen, hydroxy or an acylamino radical; G represents hydroxy, a salt thereof, or a hydrolyzable acyloxy group; r represents an integer having a value of 1 or 2; Z represents cyano, trifluoromethyl, a carboxy, a carboxylic acid ester, nitro in the 2- or 3- position relative to the azo radical, fluorosulfonyl, sulfo, halogen, an alkylsulfonyl radical; a phenylsulfonyl radical, alkylcarbonyl, a sulfamoyl radical; a carbamoyl radical, and, in formulas I or II when r is 1, Z may represent a radical having the formula Car-[X--(NR--J).sub.q ].sub.m -- wherein Car, X, J, R, q and m are as described previously; R.sup.1 represents hydrogen, an alkyl radical, an alkoxy radical or a halogen atom; E is in the 5-, 6- or 7- position relative to G and represents hydrogen, carboxy, a carboxylic acid ester, sulfo, a sulfamoyl radical, a carbamoyl radical, alkylsulfonyl radical or a phenylsulfonyl radical; Z.sup.1 represents hydrogen or Z; with the proviso that there be no more than one sulfo radical and no more than one carboxy radical present in said compound.

  蓝紫色图像染料提供化合物的化学式如下：其中：Car代表一个载体基团，根据碱性条件下的氧化作用，从该化合物中释放出可扩散的染料；m和q分别代表取值为0或1的整数；X代表双价连接基团；R代表氢或烷基；J代表从磺酰基或羰基中选择的双价基团；Q代表氢、羟基或酰胺基团；G代表羟基、其盐，或可水解的酰氧基团；r代表取值为1或2的整数；Z代表氰基、三氟甲基、一个羧基、一个羧酸酯、在与偶氮基团相对的2-或3-位上的硝基、氟磺酰基、磺酰基、卤素、一个烷基磺酰基团、苯基磺酰基团、烷基羰基、磺胺基、氨基基团；以及在化学式I或II中，当r为1时，Z可以表示具有化学式Car-[X--(NR--J).sub.q ].sub.m --的基团，其中Car、X、J、R、q和m如前所述；R.sup.1代表氢、烷基基团、烷氧基团或卤素原子；E位于与G相对的5-、6-或7-位上，表示氢、羧基、羧酸酯、磺酰基、磺胺基、羰基基团、烷基磺酰基团或苯基磺酰基团；Z.sup.1代表氢或Z；但前提是该化合物中不得有超过一个磺酰基团和一个羧基团。
• Use of Compounds for Inducing Differentiation of Mesenchymal Stem Cells to Chondrocytes
  申请人：Hwang Ki Chul

  公开号：US20130236969A1

  公开（公告）日：2013-09-12

  Use of a compound of Formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of Formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of Formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect.

  提供一种使用公式1的化合物诱导间充质干细胞向软骨细胞分化的方法，以及用于治疗软骨疾病的制药组合物，其中包括由公式1的化合物诱导的间充质干细胞分化成的软骨细胞。经过公式1化合物处理的间充质干细胞被特异性地诱导分化成软骨细胞，因此该化合物可有效治疗软骨疾病，例如关节炎，软骨损伤和软骨缺陷。
• Azo dye compounds and photographic materials
  申请人：Eastman Kodak Company

  公开号：US04268606A1

  公开（公告）日：1981-05-19

  Novel azo dye-providing compounds and photographic elements containing such compounds are described. The present compounds contain a carrier moiety which, as a function of oxidation under alkaline conditions, provides a substance having a mobility different than that of the starting compound.

  本文描述了一种新型偶氮染料提供化合物和含有这种化合物的照相元素。这些化合物包含一个载体基团，该基团在碱性条件下氧化后，提供一种与起始化合物不同的移动性物质。
• USE OF COMPOUNDS FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO CHONDROCYTES
  申请人：MSP Co., Ltd

  公开号：EP3056198A2

  公开（公告）日：2016-08-17

  Use of a compound of Formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of Formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of Formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect.

  本发明提供了一种用于诱导间充质干细胞分化为软骨细胞的式1化合物的用途，以及一种用于治疗软骨疾病的药物组合物，该药物组合物包括软骨细胞，其中间充质干细胞的分化是由式1化合物诱导的。用式 1 的化合物处理的间充质干细胞特异性地被诱导分化为软骨细胞，因此该化合物可用于有效治疗关节炎、软骨损伤和软骨缺损等软骨疾病。