3-Methoxy-furan-2-carbonsaeuremethylester | 89639-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 3-Methoxy-furan-2-carbonsaeuremethylester
• 英文别名: 3-methoxy-furan-2-carboxylic acid methyl ester；Methyl 3-methoxy-2-furoate；methyl 3-methoxyfuran-2-carboxylate
• CAS: 89639-91-8
• 化学式: C₇H₈O₄
• 分子量: 156.138
• InChiKey: UTCOLIZXFHWSOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Thienopyranones and Furanopyranones as Checkpoint Inhibitors and Modulators of Anti-Tumor Immunity
  申请人：SIGNALRX PHARMACEUTICALS, INC.

  公开号：US20200181164A1

  公开（公告）日：2020-06-11

  The invention relates to methods of treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral, bacterial or fungal infection, atherosclerosis, Type 1 or 2 diabetes, obesity, inflammatory disease, and/or SYK-associated disorder including by modulating biological processes through the inhibition of SYK alone, or in combination with inhibition of one or more of PI3 kinase including PI3K-gamma isoform, BET bromodomain proteins, CDK 4/6, and checkpoint proteins, comprising the administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts thereof) as defined herein.
• Single Molecule Compounds Providing Multi-Target Inhibition of BTK and Other Proteins and Methods of Use Thereof
  申请人：SignalRx Pharmaceuticals, Inc.

  公开号：US20210300939A1

  公开（公告）日：2021-09-30

  The invention relates to compounds useful for inhibiting BTK and at least one other protein and to methods of treating diseases including cancer by administration of a compound(s) of Formula I-IV or pharmaceutically acceptable salts thereof as defined herein.