2-(dimethylamino)-4-oxo-4H-1-benzopyran-6-yl dimethylcarbamate | 130736-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(dimethylamino)-4-oxo-4H-1-benzopyran-6-yl dimethylcarbamate
• 英文别名: [2-(dimethylamino)-4-oxochromen-6-yl] N,N-dimethylcarbamate
• CAS: 130736-27-5
• 化学式: C₁₄H₁₆N₂O₄
• 分子量: 276.292
• InChiKey: QQTZFOXKNUQCGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二氯亚甲基二甲基氯化铵 、 2,5-二羟基苯乙酮 生成 2-(dimethylamino)-4-oxo-4H-1-benzopyran-6-yl dimethylcarbamate
  参考文献：
  名称：

  A novel synthesis of 2-aminochromones via phosgeniminium salts

  摘要：

  A novel method for the synthesis of antiplatelet 2-aminochromones making use of the reaction of 2'-hydroxyacetophenone-BF2 Complexes with phosgeniminium chlorides has been developed. Aqueous hydrolysis of the intermediate beta-chlorovinylogous amide-BF2 complex affords the 2-aminochromone in good yield, without the need for chromatographic purification.

  DOI：

  10.1021/jo00050a025

文献信息

• A novel synthesis of 2-aminochromones via phosgeniminium salts
  作者：Joel Morris、Donn G. Wishka、Yue Fang

  DOI：10.1021/jo00050a025

  日期：1992.11

  A novel method for the synthesis of antiplatelet 2-aminochromones making use of the reaction of 2'-hydroxyacetophenone-BF2 Complexes with phosgeniminium chlorides has been developed. Aqueous hydrolysis of the intermediate beta-chlorovinylogous amide-BF2 complex affords the 2-aminochromone in good yield, without the need for chromatographic purification.