(4Z)-2-(naphthalen-1-yl)-4-[4-(propan-2-yl)benzylidene]-1,3-oxazol-5(4H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4Z)-2-(naphthalen-1-yl)-4-[4-(propan-2-yl)benzylidene]-1,3-oxazol-5(4H)-one
• 英文别名: (4Z)-2-naphthalen-1-yl-4-[(4-propan-2-ylphenyl)methylidene]-1,3-oxazol-5-one
• 化学式: C₂₃H₁₉NO₂
• 分子量: 341.4
• InChiKey: CIYSKMWPYWCMEO-STZFKDTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL COMPOUND AND COMPOSITION FOR PREVENTION OR TREATMENT OF RESPIRATORY DISEASES COMPRISING SAME AS ACTIVE INGREDIENT
  申请人：Yonsei University, University-Industry Foundation(UIF).

  公开号：EP3949963A1

  公开（公告）日：2022-02-09

  The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.

  本发明涉及一种新化合物，以及包括该新化合物、其E-或Z-异构体、其光学异构体、两种异构体的混合物、其前体、其药用盐或其溶剂结晶体作为活性成分的用于预防或治疗呼吸道疾病的组合物。
• NOVEL COMPOUND AND METHOD FOR PREVENTING OR TREATING OF RESPIRATORY DISEASES COMPRISING THE SAME AS AN ACTIVE INGREDIENT
  申请人：YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

  公开号：US20220193041A1

  公开（公告）日：2022-06-23

  The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.
• [EN] NOVEL COMPOUND AND COMPOSITION FOR PREVENTION OR TREATMENT OF RESPIRATORY DISEASES COMPRISING SAME AS ACTIVE INGREDIENT<br/>[FR] NOUVEAU COMPOSÉ ET COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES RESPIRATOIRES COMPRENANT CELUI-CI COMME PRINCIPE ACTIF<br/>[KO] 신규 화합물 및 이를 유효성분으로 포함하는 호흡기 질환의 예방 또는 치료용 조성물
  申请人：UNIV YONSEI IACF

  公开号：WO2020204602A1

  公开（公告）日：2020-10-08

  본 발명은 신규 화합물과, 상기 신규 화합물, 그 E- 또는 Z- 이성질체, 그 광학 이성질체, 그 이성질체 2개 혼합물, 그 전구체, 그 약학적으로 허용가능한 염 또는 그 용매화물을 유효 성분으로 포함하는 호흡기 질환의 예방 또는 치료용 조성물에 관한 것이다.