2,4-difluoro-1-hydroxynaphthalene | 56874-96-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,4-difluoro-1-hydroxynaphthalene
• 英文别名: 2,4-difluoronaphthalen-1-ol；2,4-Difluor-1-naphthol
• CAS: 56874-96-5
• 化学式: C₁₀H₆F₂O
• 分子量: 180.154
• InChiKey: DWRQUONHTPNSHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟萘-1-醇 在 cesium fluoroxysulphate 、 三氟化硼 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以89%的产率得到2,4-difluoro-1-hydroxynaphthalene
  参考文献：
  名称：

  Fluorination with cesium fluoroxysulfate. Room temperature fluorination of benzene and naphthalene derivatives

  摘要：

  DOI：

  10.1021/jo00219a032

文献信息

• Promotional effect of ionic liquids in electrophilic fluorination of phenols
  作者：Gennady I. Borodkin、Innokenty R. Elanov、Vyacheslav G. Shubin

  DOI：10.24820/ark.5550190.p010.164

  日期：——

  The influence of a stoichiometric amount of ionic liquids (IL) on the fluorination of phenols in various solvents has been studied. The fluorination of phenol, 1-naphthol and resorcinol was carried out using 1-chloromethyl-4-fluoro-l,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF4, Selectfluor (TM)) with the formation of 2-fluoro-, 4-fluorophenol, 2-fluoro-, 4-fluoronaphthol and 4-fluoro-, 4,6-difluoro-benzene-l,3-diol as the main products. The use of a stoichiometric amount of ionic liquid as an additive results in acceleration of the reactions. The effect is most significant at low temperatures. It has been found that solvent polarity has an essential effect on the difference in yields of fluoroproducts obtained in the presence of IL and without it.
• Fluorination with cesium fluoroxysulfate. Room temperature fluorination of benzene and naphthalene derivatives
  作者：Stojan Stavber、Marko Zupan

  DOI：10.1021/jo00219a032

  日期：1985.9