[6-(Dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [6-(Dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium
• 化学式: C25H25N2O3+
• 分子量: 401.5
• InChiKey: WAWRKBQQBUDAMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL TEMPERATURE-SENSITIVE FLUORESCENT COMPOUND AND APPLICATION THEREOF
  申请人：SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES

  公开号：US20160376247A1

  公开（公告）日：2016-12-29

  Provided is a compound represented by formula I, wherein R 9 is a C1-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, R 5 , R 6 , R 7 , and R 8 are alkyl groups or H, and R 1 , R 2 , R 3 , and R 4 are H or a lower hydrocarbyl group. Or, R 9 is a C2-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, and R 5 is connected to R 1 , R 6 is connected to R 2 , R 7 is connected to R 3 , R 8 is connected to R 4 to form six-membered rings. The present compound is temperature-sensitive and can enter into cells. An intracellular temperature distribution image having high spatial and temporal resolution can thus be obtained. The present compound can also perform distribution calibration on a temperature-sensitive fluorescent compound. Also provided is a method for measuring temperature distribution within a living cell, and a corresponding detection kit. The method satisfies the requirements of small size measurement and rapid measurement, thereby achieving high resolution in terms of space and time.

  提供的化合物由式I表示，其中R9是一个C1-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，R5、R6、R7和R8是烷基基团或氢，而R1、R2、R3和R4是氢或较低烃基基团。或者，R9是一个C2-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，而R5连接到R1，R6连接到R2，R7连接到R3，R8连接到R4形成六元环。这种化合物对温度敏感，可以进入细胞。因此，可以获得具有高空间和时间分辨率的细胞内温度分布图像。这种化合物还可以对温度敏感的荧光化合物进行分布校准。还提供了一种测量活细胞内温度分布的方法和相应的检测工具包。该方法满足了小尺寸测量和快速测量的要求，从而在空间和时间上实现高分辨率。
• FLUORESCENT POLYMERIC MATERIALS CONTAINING LIPID SOLUBLE RHODAMINE DYES
  申请人：LAM Joe Y.L.

  公开号：US20090072197A1

  公开（公告）日：2009-03-19

  Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.

  本发明披露了一种包括聚合物和一种或多种脂溶性罗丹明染料的荧光聚合物材料。该材料在制备多色微粒，特别是多色聚苯乙烯微粒方面特别有用，用于在单个样品中进行多重分析多种分析物。当受到光源的激发时，该材料会发出基于其中染料的性质、浓度和比例的独特发射。本发明还披露了制备和使用该材料的方法。
• Fluorescent Polymeric Materials Containing Lipid Soluble Rhodamine Dyes
  申请人：LAM Joe Y.L.

  公开号：US20110226994A1

  公开（公告）日：2011-09-22

  Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.

  本发明公开了荧光聚合物材料，包括聚合物和一种或多种脂溶性罗丹明染料。该材料在制备多色微粒，尤其是多色聚苯乙烯微粒方面特别有用，用于在单个样品中进行多重分析。当受到光源的激发时，该材料会发出基于其中染料的性质、浓度和比例的独特发射。本发明还公开了制备和使用该材料的方法。