5-(dimethylamino)-N-(3,3-dimethylbutyl)naphthalene-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(dimethylamino)-N-(3,3-dimethylbutyl)naphthalene-1-sulfonamide
• 化学式: C₁₈H₂₆N₂O₂S
• 分子量: 334.5
• InChiKey: HNKRYGJXILNMGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors
  申请人：Silverman Richard B.

  公开号：US20140066635A1

  公开（公告）日：2014-03-06

  Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.

  选择性神经型一氧化氮合酶（nNOS）抑制剂化合物设计为具有一个或多个噻吩-2-羧酰胺取代基，以提高生物利用度。
• SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY
  申请人：Butt Tauseef R.

  公开号：US20110319293A1

  公开（公告）日：2011-12-29

  Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided.

  提供了合成蛋白酶底物和方法，有助于识别蛋白酶的底物，特别是泛素、泛素样或蛋白酶体蛋白的底物。
• US20140256958A1
  申请人：——

  公开号：US20140256958A1

  公开（公告）日：2014-09-11
• Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors
  申请人：Silverman Richard B.

  公开号：US20160152590A1

  公开（公告）日：2016-06-02

  Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
• SEQUENCE-DEFINED POLYMERS AND METHODS OF MAKING SAME AND USING SAME
  申请人：Cornell University

  公开号：US20200299461A1

  公开（公告）日：2020-09-24

  Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.