Synthesis of a first thiophene containing analog of the HIV protease inhibitor nelfinavir
作者:Carlo Bonini、Lucia Chiummiento、Margherita De Bonis、Maria Funicello、Paolo Lupattelli
DOI:10.1016/j.tetlet.2004.02.026
日期:2004.3
A stereoselective and efficient preparation of a thiophene containing intermediate 2 from ethyl 3-thienyl propenoate 4 as the core of new possible HIV protease inhibitors is described. The chiral intermediate has been successfully used for the preparation of the analog I of the potent HIV inhibitor nelfinavir. (C) 2004 Elsevier Ltd. All rights reserved.