3-amino-1-(benzo[d] [1,3]dioxol-5-yl)-1H-benzo[f]chromene-2-carbonitrile | 130715-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-amino-1-(benzo[d] [1,3]dioxol-5-yl)-1H-benzo[f]chromene-2-carbonitrile
• 英文别名: 3-amino-1-(1,3-benzodioxol-5-yl)-1H-benzo[f]chromene-2-carbonitrile
• CAS: 130715-43-4
• 化学式: C₂₁H₁₄N₂O₃
• 分子量: 342.354
• InChiKey: GBUCEWAZTWQMTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (苯并[3,4-d]1,3-二氧杂烷-5-亚甲基)甲烷-1,1-二甲腈 、 2-萘酚 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 3-amino-1-(benzo[d] [1,3]dioxol-5-yl)-1H-benzo[f]chromene-2-carbonitrile
  参考文献：
  名称：

  Abdel-Latif, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 7, p. 664 - 666

  摘要：

  DOI：

文献信息

• Clean, One‐Pot Synthesis of Naphthopyran Derivatives in Aqueous Media
  作者：Tong‐Shou Jin、Jian‐She Zhang、Li‐Bin Liu、Ai‐Qing Wang、Tong‐Shuang Li

  DOI：10.1080/00397910600632096

  日期：2006.6

  Abstract A general and practical one‐pot synthesis of naphthopyran derivatives using hexadecyltrimethylammonium bromide (HTMAB) as catalyst (10 mol%) is described. This method provides several advantages such as neutral conditions, high yields and simple workup procedure. The catalyst is low cost, facile, active, environmentally friendly, and reusable. In addition, water is chosen as a green solvent

  摘要描述了使用十六烷基三甲基溴化铵 (HTMAB) 作为催化剂 (10 mol%) 的通用和实用的萘并吡喃衍生物的一锅法合成。这种方法提供了几个优点，例如中性条件、高产率和简单的后处理程序。该催化剂成本低、操作简便、活性高、环境友好、可重复使用。此外，选择水作为绿色溶剂。
• Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents
  作者：Mazaahir Kidwai、Shilpi Saxena、M. Khalilur Rahman Khan、Sharanjit S. Thukral

  DOI：10.1016/j.bmcl.2005.06.041

  日期：2005.10

  A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. (c) 2005 Elsevier Ltd. All rights reserved.
• Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism
  作者：Heba K.A. El-Mawgoud、Ahmed M. Fouda、Mohammed A.A. El-Nassag、Ahmed A. Elhenawy、Mohammed Y. Alshahrani、Ahmed M. El-Agrody

  DOI：10.1016/j.cbi.2022.109838

  日期：2022.3
• ABDEL-LATIF, FATHY FAHIM, INDIAN J. CHEM. B, 29,(1990) N, C. 664-666
  作者：ABDEL-LATIF, FATHY FAHIM

  DOI：——

  日期：——