4-Acetoxy Tamoxifen

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-Acetoxy Tamoxifen
• 英文别名: [4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenyl] acetate
• 化学式: C₂₈H₃₁NO₃
• 分子量: 429.5
• InChiKey: SGKPMDROJNZRQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ERR MODULATORS AND USES THEREOF
  申请人：CITY OF HOPE

  公开号：US20180297923A1

  公开（公告）日：2018-10-18

  Disclosed herein, inter alia, are compositions and methods useful for treating non-alcoholic fatty liver diseases.

  披露的内容包括但不限于，用于治疗非酒精性脂肪肝疾病的组合物和方法。
• Compounds and methods for treating breast cancer and other diseases
  申请人：Forman Barry

  公开号：US20050096384A1

  公开（公告）日：2005-05-05

  Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activation of estrogen receptors and/or estrogen related receptors.

  揭示了用于创造新化合物和已知化合物的新型组合物和新方法。还揭示了使用这些新化合物治疗与降低或预防雌激素受体和/或雌激素相关受体激活有关的各种疾病的方法。
• ERR modulators and uses thereof
  申请人：CITY OF HOPE

  公开号：US10590056B2

  公开（公告）日：2020-03-17

  Disclosed herein, inter alia, are compositions and methods useful for treating non-alcoholic fatty liver diseases.

  本文特别公开了用于治疗非酒精性脂肪肝的组合物和方法。
• USE OF TRIPHENYLBUTENE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1127045A2

  公开（公告）日：2001-08-29
• COMPOUNDS AND METHODS FOR TREATING BREAST CANCER AND OTHER DISEASES
  申请人：Forman Barry

  公开号：US20090176305A1

  公开（公告）日：2009-07-09

  Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activation of estrogen receptors and/or estrogen related receptors.