(3R,4R)-3-Methyl-4-(1-trityl-1H-imidazol-4-yl)-pyrrolidin-2-one | 325688-91-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (3R,4R)-3-Methyl-4-(1-trityl-1H-imidazol-4-yl)-pyrrolidin-2-one
• 英文别名: (3R,4R)-3-methyl-4-(1-tritylimidazol-4-yl)pyrrolidin-2-one
• CAS: 325688-91-3
• 化学式: C₂₇H₂₅N₃O
• 分子量: 407.515
• InChiKey: KMVNKOFFCLFKTP-YKSBVNFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3R,4R)-3-Methyl-4-(1-trityl-1H-imidazol-4-yl)-pyrrolidin-2-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到4-[(3R,4R)-4-methylpyrrolidin-3-yl]-1-trityl-1H-imidazole
  参考文献：
  名称：

  An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

  摘要：

  A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00380-3
• 作为产物：
  描述：

  (4S)-4-benzyl-3-[(2R,3R)-2-methyl-4-nitro-3-(1-tritylimidazol-4-yl)butanoyl]-1,3-oxazolidin-2-one 在 镍 氢气 作用下， 以 乙醇 为溶剂， 以72%的产率得到(3R,4R)-3-Methyl-4-(1-trityl-1H-imidazol-4-yl)-pyrrolidin-2-one
  参考文献：
  名称：

  An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

  摘要：

  A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00380-3

文献信息

• An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)
  作者：Robert Aslanian、Gary Lee*、Radha V Iyer、Neng-Yang Shih、John J Piwinski、Richard W Draper、Andrew T McPhail

  DOI：10.1016/s0957-4166(00)00380-3

  日期：2000.10

  A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Elsevier Science Ltd. All rights reserved.