10',16'-Bis(3,4,5-trifluorophenyl)-13,13'-spirobi[13-azoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene]

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 10',16'-Bis(3,4,5-trifluorophenyl)-13,13'-spirobi[13-azoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene]
• 化学式: C56H34F6N+
• 分子量: 834.9
• InChiKey: BMPQCFDPJNKELJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.5
• 重原子数：
  63
• 可旋转键数：
  2
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Method for Producing Asymmetric Alkyl Compound Using Alkali-Treated Solid SAupport, and Alkali-Treated Solid Support Used in this Method
  申请人：Koshima Hideko

  公开号：US20070225157A1

  公开（公告）日：2007-09-27

  An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having a catalytic action which causes the asymmetric synthesis reaction to proceed with (ii) an alkali-treated solid support obtained by treating with an alkaline substance a solid support made of an inorganic compound. By placing this mixture at room temperature, the asymmetric alkylation occurs between the glycine imine ester and the alkyl halide which are catalyzed by the asymmetric catalyst in an alkali-treated solid support contained in the mixture, and the asymmetric alkylation is completed in about 1 hour. Thus, a highly optically pure asymmetric alkyl compound can be obtained in high yield. Therefore, it is possible to provide the asymmetric alkyl compound producing method which does not require the agitation of the solvent, completes the asymmetric alkylation efficiently and stably in a short time, and synthesizes a highly optically pure asymmetric alkyl compound in high yield.

  本发明的一种不对称烷基化合物的制备方法包括以下步骤：将（i）含有甘氨酸亚胺酯、烷基卤化物和具有催化作用的不对称催化剂的反应液与（ii）经过碱性物质处理的无机化合物制成的固体支撑物混合进行不对称合成反应的合成步骤。将该混合物放置于室温下，甘氨酸亚胺酯和烷基卤化物之间的不对称烷基化作用在混合物中含有碱性处理的固体支撑物的不对称催化剂的催化下发生，并在约1小时内完成不对称烷基化。因此，可以高产率地获得高度光学纯的不对称烷基化合物。因此，可以提供一种不需要溶剂搅拌，能够在短时间内高效稳定地完成不对称烷基化反应，并高产率合成高度光学纯的不对称烷基化合物的方法。
• PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF
  申请人：Maruoka Keiji

  公开号：US20090054679A1

  公开（公告）日：2009-02-26

  The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.

  本发明提供了一种使用醛亚胺型席夫碱制备α-氨基酸的不对称单取代烷基化合物的方法，其由特定的公式表示。在本发明的方法中，通过在存在光学活性季铵盐相转移催化剂和无机碱的介质中烷基化醛亚胺型席夫碱的过程，随后在达到化学计量反应完成时间之前的时间中止反应，从而可以获得具有高光学纯度的单取代烷基化产物。
• OPTICALLY ACTIVE DIBENZAZEPINE DERIVATIVES
  申请人：Kubota Yasushi

  公开号：US20110034688A1

  公开（公告）日：2011-02-10

  It is to provide a novel optically active dibenzazepine derivative having a high utility value as an asymmetric phase-transfer catalyst. It is an optically active 6,7-dihydro-5H-dibenzo[c,e]azepine derivative represented by the following formula (1′), (wherein R represents a divalent organic group for cross-linking the 1 st position and the 11 th position; R 1 and R 2 are the same or different, and represent a hydrogen atom, halogen atom, or organic group, or R 1 and R 2 together represent a divalent organic group; R 3 ′and R 4 ′ are the same or different and represent a monovalent organic group, or R 3 ′ and R 4 ′ together form an organic group that forms a cyclic structure comprising an onium nitrogen atom; Ar represents a monovalent organic group; * represents optical activity, i.e., that one axially asymmetric isomer is present in excess of the other axially asymmetric isomer with respect to a bond axis that constitutes the biphenyl structure of the compound; and X − represents a counter anion).
• US7709678B2
  申请人：——

  公开号：US7709678B2

  公开（公告）日：2010-05-04
• US8507669B2
  申请人：——

  公开号：US8507669B2

  公开（公告）日：2013-08-13