ZINC ethylenebis (dithiocarbamic acid)

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: ZINC ethylenebis (dithiocarbamic acid)
• 英文别名: 2-(dithiocarboxyamino)ethylcarbamodithioic acid;zinc
• 化学式: C4H8N2S4Zn
• 分子量: 277.8
• InChiKey: RGALBBQJPFDFCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.71
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  3

ADMET

代谢

ETU和DIDT（5,6-二氢-3 H-咪唑（2,1-C）-1,2,4-二噻唑-3-硫酮）是处理了锌EB的大鼠尿液中发现的主要代谢物，并且在呼出的空气中检测到了二硫化碳。

ETU and DIDT /(5,6-dihydro-3 H-imidazo(2,1-C)-1,2,4-dithiazole-3-thione)/ were the major metabolites found in the urine of rats treated with zineb, and carbon disulfide was detected in the expired air.

来源:Hazardous Substances Data Bank (HSDB)

代谢

杀真菌剂代森锌（锌乙撑双硫代氨基甲酸酯）在大鼠和卷尾猴体内的代谢已经进行了研究。在两种物种中，相对较大比例（21-22%）的原始给药代森锌可以在排泄物中检测为乙撑硫脲（ETU）……进一步的比例（2-5%）被确定为乙烯脲，这是ETU的代谢物。在卷尾猴中进行的比较实验结果显示，ETU在排泄物存在的情况下对光敏感，因此突显了在黑暗中进行研究的重要性。

The metabolism of the fungicide zineb, (zinc ethylenebisdithiocarbamate), has been studied in the rat and the marmoset. In both species a relatively large proportion (21-22%) of the original zineb administered was detectable in the excreta as ethylenethiourea (ETU) ... A further proportion (2-5%) was determined to be ethyleneurea which is a metabolite of ETU. Results of comparative experiments in marmosets revealed that ETU was photolabile in the presence of excreta, thus showing the importance of conducting the studies in the dark.

来源:Hazardous Substances Data Bank (HSDB)

代谢

Zineb ... 在大鼠体内代谢为碳二硫化物，通过呼吸排出，以及代谢为乙撑亚硫脲 ... 和乙烯双(异硫氰酸酯)硫化物（ebis）... 这些物质通过尿液排出。

Zineb ... Is metabolized in rats to carbon disulfide, which is expired, and to ethylenethiourea ... and ethylenebis(isothiocyanate)sulfide (ebis) ... which are excreted in urine.

来源:Hazardous Substances Data Bank (HSDB)

代谢

乙烯硫脲是植物中的主要代谢物。乙烯硫脲单磺酸和可能的乙烯硫脲二磺酸以及硫磺也会形成。

Ethylenethiourea is the major metabolite in plants. Ethylenethiuram monosulfide and presumably ethylenethiuram disulfide and sulfur are also formed.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性证据不足。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：福美锌

IARC Carcinogenic Agent:Zineb

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第12卷：（1976年）一些氨基甲酸酯、硫代氨基甲酸酯和脒基脒

IARC Monographs:Volume 12: (1976) Some Carbamates, Thiocarbamates and Carbazides

来源:International Agency for Research on Cancer (IARC)

毒理性

• 暴露途径

这种物质可以通过吸入被身体吸收。

The substance can be absorbed into the body by inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

摄入的代森锌大约有70-75%通过大鼠的消化道，并在24-72小时内出现在粪便中。

... Approx 70-75% of ingested zineb passed through the gastrointestinal tract of rats and appeared in the feces within 24-72 hr.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

只有11%到17%的辛内布剂量从大鼠的消化道被吸收。一些额外的物质可能在肠道分解后被吸收。在不同膳食水平下，68.5%到74.9%的摄入物质在粪便中未改变地被回收。

... Only 11 to 17% of an oral dose of zineb is absorbed from the gastrointestinal tract of the rat. Some additional material may be absorbed following breakdown in the intestine. At different dietary levels 68.5 to 74.9% of the ingested material was recovered unchanged in the feces.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在短期静态生物积累实验中，使用(14)C标记的亚乙基双硫代氨基甲酸锌（乙撑双）和甲基双硫代氨基甲酸锌（齐拉姆），两种化合物都迅速通过组织传播。整体身体消除是迅速的，16天净化期结束时，齐拉姆和乙撑双的初始放射性分别保留了45%和25%。色素组织似乎也是主要的分布位点。这可能与化合物及其降解产物对黑色素或与酪氨酸酶（一种参与黑色素合成的含铜酶）的亲和力有关。放射自显影还揭示了甲状腺滤泡的高度标记。结果表明，二硫代氨基甲酸盐在各种组织中具有选择性定位，据报道这些组织是其毒性作用的目标器官。

In short-term static bioaccumulation experiments with (14)C-labeled zinc ethylenebisidithiocarbamate (zineb) and zinc dimethyldithiocarbamate (ziram) both compounds were rapidly disseminated through the tissues. Whole body elimination was rapid with 45% and 25% of the initial radioactivity from ziram, and zineb, respectively, being retained by the end of the 16 day depuration period. Pigmented tissues appeared to be major distribution sites as well. This may be related to the affinity of the compounds and/or their degradation products to melanin or to complexion with phenoloxidase, a copper containing enzyme involved in melanin synthesis. Autoradiography also revealed a high labeling of thyroid follicles. The results show that dithiocarbamates are selectively localized in various tissues, reported to be the target organs for their toxic actions.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

乙烯硫脲是乙烯基双二硫代氨基甲酸/酸/杀菌剂的代谢物，在大鼠单次口服锌巴后16天内监测其尿液和粪便中的排泄情况。48小时后，排泄出的乙烯硫脲中有86%在尿液中，14%在粪便中。尿液排泄在摄入后24小时达到峰值，此时已排泄出总尿液乙烯硫脲的52%。在整个研究期间，尿液中持续排泄低水平的乙烯硫脲，到研究结束时，口服锌巴剂量的5.1%作为尿液中的乙烯硫脲被排泄。乙烯硫脲的粪便排泄在3天内完成。

Urinary and fecal excretion of ethylene thiourea, a metabolite of ethylene-bis-dithiocarbamic /acid/ fungicides, was monitored in rats for 16 days after they were administered a single oral dose of zineb. After 48 hr, 86% of the excreted ethylene thiourea was in the urine, 14% in the feces. Urinary excretion peaked at 24 hr after ingestion, at which time 52% of the total urinary ethylene thiourea had been excreted. Low levels of ethylene thiourea excretion continued in urine for the length of the study, by which time 5.1% of the zineb /oral dose/ was excreted as urinary ethylene thiourea. Fecal excretion of ethylene thiourea was complete after 3 days.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为试剂：
  描述：

  福美双 、 、 N-trichloromethylmercaptotetrahydrophthalimide 、 二氰蒽醌 、 敌菌灵 、 、 、 、 百菌清 、 、 、 链霉素 、 2-amino-2-[(2R,3S,5S,6R)-5-amino-2-methyl-6-[(2S,3S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]iminoacetic acid;hydron;chloride 、 放线菌酮 在 ZINC ethylenebis (dithiocarbamic acid) 、 Manganese ethylenebis (dithiocarbamic acid) 、 锌 、 代森锰锌 、 Bis (dimethyldithiocarbamic acid) ethylenebis (dithiocarbamic acid) dizinc 作用下， 生成 6-Acetoxy-2,4-dimethyl-m-dioxin
  参考文献：
  名称：

  Volatilizer

  摘要：

  本发明涉及一种能够充分稳定地提供活性成分的蒸发装置。该发明的一种实施例包括一个保留容器，用于保持含有活性成分的液体配方，一个液体吸收机制，用于从保留容器中吸收液体配方，一个蒸发机制，用于蒸发吸收到液体吸收机制中的液体配方的活性成分，以及调节手段，用于调节活性成分的蒸发。

  公开号：

  US20060231213A1