perfluoroisobutylcyclohexane | 80274-98-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: perfluoroisobutylcyclohexane
• 英文别名: perfluoro-i-butylcyclohexane；Perfluoro-(2-methylpropyl)-cyclohexane；1,1,2,2,3,3,4,4,5,5,6-undecafluoro-6-[1,1,2,3,3,3-hexafluoro-2-(trifluoromethyl)propyl]cyclohexane
• CAS: 80274-98-2
• 化学式: C₁₀F₂₀
• 分子量: 500.078
• InChiKey: KOIDEQKLBFUNQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  异丁基环己烷 在 fluorine 、 sodium fluoride 作用下， 反应 120.0h， 以27.6%的产率得到perfluoroisobutylcyclohexane
  参考文献：
  名称：

  The synthesis of highly fluorinated alkylcyclohexanes for use as oxygen carriers and the 19F and 13C NMR spectra of alkylcyclohexanes

  摘要：

  Perfluoroalkylcyclohexanes are promising candidates for oxygen carriers. The perfluoroalkylcyclohexane analogues and 1H-perfluoroalkylcyclohexanes of n-propylcyclohexane, i-propylcyclohexane, n-butylcyclohexane, s-butylcyclohexane, i-butylcyclohexane and t-butylcyclohexane were prepared and characterized. Their properties and NMR spectra are discussed.

  DOI：

  10.1016/s0022-1139(00)85000-9

文献信息

• THERAPEUTIC OR PROPHYLACTIC AGENT FOR VASOCONSTRICTION
  申请人：Next 21 K.K.

  公开号：EP2198869A1

  公开（公告）日：2010-06-23

  An object of the present invention is to provide an agent for treating or preventing vasospasm. An obj ect of the present invention is to provide an agent for treating or preventing cerebral vasospasm as well as arterial vasospasm. Further, an obj ect of the present invention is to provide an agent for treating or preventing cerebral ischemia and cerebral infarction. The above problems are solved by an agent for treating and preventing vasospasm, cerebral ischemia, or cerebral infarction, comprising trehalose as the active ingredient. It is possible, by using such a trehalose-comprising agent, to suppress phenomena such as contraction of blood vessel and thickening of tunica intima and tunica media and to prevent or treat vasospasm and vasospasm-dependent diseases.

  本发明的目的是提供一种治疗或预防血管痉挛的药剂。本发明的目的是提供一种治疗或预防脑血管痉挛以及动脉血管痉挛的制剂。此外，本发明的一个目的是提供一种治疗或预防脑缺血和脑梗塞的制剂。 治疗和预防血管痉挛、脑缺血或脑梗塞的制剂以曲哈洛糖为活性成分，可以解决上述问题。通过使用这种含曲哈糖的制剂，可以抑制血管收缩、血管内膜和中膜增厚等现象，预防或治疗血管痉挛和血管痉挛依赖性疾病。
• TREHALOSE FOR THE TREATMENT OR PREVENTION OF VASOSPASM
  申请人：Next 21 K.K.

  公开号：EP2198869B1

  公开（公告）日：2015-09-16
• US8283337B2
  申请人：——

  公开号：US8283337B2

  公开（公告）日：2012-10-09
• The synthesis of highly fluorinated alkylcyclohexanes for use as oxygen carriers and the 19F and 13C NMR spectra of alkylcyclohexanes
  作者：Wen-Huey Lin、Richard J. Lagow

  DOI：10.1016/s0022-1139(00)85000-9

  日期：1990.12

  Perfluoroalkylcyclohexanes are promising candidates for oxygen carriers. The perfluoroalkylcyclohexane analogues and 1H-perfluoroalkylcyclohexanes of n-propylcyclohexane, i-propylcyclohexane, n-butylcyclohexane, s-butylcyclohexane, i-butylcyclohexane and t-butylcyclohexane were prepared and characterized. Their properties and NMR spectra are discussed.