2-<4-(2-hydroxyethyl)-1-piperazinyl>-1-cycloheptanone | 89747-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-<4-(2-hydroxyethyl)-1-piperazinyl>-1-cycloheptanone
• 英文别名: 2-[4-(2-Hydroxyethyl)piperazin-1-yl]cycloheptan-1-one
• CAS: 89747-07-9
• 化学式: C₁₃H₂₄N₂O₂
• mdl: MFCD13155994
• 分子量: 240.346
• InChiKey: JPQDXHYQIOBCDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.923
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(2-oxo-3,5,7-cycloheptatrien-1-yl)-1-piperazineethanol 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以13%的产率得到2-<4-(2-hydroxyethyl)-1-piperazinyl>-1-cycloheptanone
  参考文献：
  名称：

  Troponoids. 6. Troponylpiperazines: a new class of dopamine agonists

  摘要：

  A series of alkyltroponylpiperazine derivatives was synthesized and evaluated for dopaminergic activity in rats rendered hypokinetic by the bilateral injection of 6-hydroxydopamine (6-OHDA) into the anterolateral hypothalamus. Several members of the series were active, and a structure-activity relationship is presented. A few selected compounds were also evaluated with regard to their ability to induce contralateral rotational behavior in rats with a unilateral 6-OHDA-induced lesion of the nigrostriatal dopamine pathway. The compounds were compared to bromocriptine. The results indicate that dopaminergic activity is very sensitive to small changes in the troponylpiperazine moiety.

  DOI：

  10.1021/jm00373a012

文献信息

• Troponoids. 6. Troponylpiperazines: a new class of dopamine agonists
  作者：Jehan Bagli、T. Bogri、Katherine Voith

  DOI：10.1021/jm00373a012

  日期：1984.7

  A series of alkyltroponylpiperazine derivatives was synthesized and evaluated for dopaminergic activity in rats rendered hypokinetic by the bilateral injection of 6-hydroxydopamine (6-OHDA) into the anterolateral hypothalamus. Several members of the series were active, and a structure-activity relationship is presented. A few selected compounds were also evaluated with regard to their ability to induce contralateral rotational behavior in rats with a unilateral 6-OHDA-induced lesion of the nigrostriatal dopamine pathway. The compounds were compared to bromocriptine. The results indicate that dopaminergic activity is very sensitive to small changes in the troponylpiperazine moiety.