3-ethoxy-acrylimidic acid ethyl ester; hydrochloride | 71470-38-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: 3-ethoxy-acrylimidic acid ethyl ester; hydrochloride
• 英文别名: 3-Aethoxy-acrylimidsaeure-aethylester; Hydrochlorid；Ethyl 3-ethoxyacrylimidate hydrochloride；ethyl 3-ethoxyprop-2-enimidate;hydrochloride
• CAS: 71470-38-7
• 化学式: C₇H₁₃NO₂*ClH
• 分子量: 179.647
• InChiKey: SSWRFXWOCJHUSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  42.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙醇 、 3-ethoxy-acrylimidic acid ethyl ester; hydrochloride 生成 3,3-二乙氧基丙酸乙酯
  参考文献：
  名称：

  Clinical Applications of Serum Placental Protein 14 (PP14) Measurement in the IVF-ET Cycle

  摘要：

  AbstractObjective: Placental protein 14 (PP14) is known to be one of the endometrial proteins that reflect endometrial functioning throughout the menstrual cycle. In this study, we examined PP14 as a marker for human endometrial receptivity in order to predict the outcome of in vitro fertilization and the embryo‐transfer (IVF‐ET) cycle.Patients and Methods: The subjects were 72 women who had 96 IVF‐ET cycles and who were examined at Tokyo Medical University Hospital during the period of January 1998 to June 1998 because of mechanical or unexplained infertility for a duration of at least 2 years. Serum samples were collected from all patients during treatment cycles, and serum PPI4 concentrations were measured by a newly established enzyme‐linked immunosorbent assay (ELISA).Results: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0.01). PP14 concentrations were higher in patients with endometria that exhibited homogenous patterns and that were more than 7 mm thicker than in other patients, as determined by ultrasound on the day of oocyte collection (p < 0.005). The pregnancy rates of patients with homogeneous patterns were lower than those of patients showing a trilaminar pattern. No pregnancies were observed when serum PP14 concentrations were greater than 6.85 U/l on the day of oocyte collection.Conclusion: PP14 might be a useful marker for human endometrial receptivity to predict the outcome of IVF‐ET cycles.

  DOI：

  10.1111/j.1447-0756.2000.tb01325.x

文献信息

• Pyrimidinyl cephalosporanic acid derivatives and pharmaceutical
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04395411A1

  公开（公告）日：1983-07-26

  This invention relates to novel 7-pyrimidinyl and pyridinyl acetamido cephem derivatives of high antibacterial activity.

  本发明涉及一种具有高抗菌活性的新型7-嘧啶基和吡啶基乙酰胺头孢菌素衍生物。
• Amino or acylamino-substituted pyrimidinyl cephalosporanic acid
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04267176A1

  公开（公告）日：1981-05-12

  The invention relates to novel amino or acylamino-substituted pyrimidinyl cephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of antibacterial activity, to processes for the preparation thereof, and to pharmaceutical compositions comprising the novel cephalosporanic acid derivatives.

  本发明涉及一种新型氨基或酰胺基取代的嘧啶基头孢菌素酸衍生物及其相应的药物可接受盐，具有抗菌活性，以及其制备方法和包括新型头孢菌素酸衍生物的制药组合物。
• Clinical Applications of Serum Placental Protein 14 (PP14) Measurement in the IVF-ET Cycle
  作者：Yoshichika Suzuki、Rikikazu Sugiyama、Noritaka Fukumine、Saburo Usuda、Hiroe Itoh、Keiichi Isaka、Masaomi Takayama、Borge Teisner

  DOI：10.1111/j.1447-0756.2000.tb01325.x

  日期：2000.8

  AbstractObjective: Placental protein 14 (PP14) is known to be one of the endometrial proteins that reflect endometrial functioning throughout the menstrual cycle. In this study, we examined PP14 as a marker for human endometrial receptivity in order to predict the outcome of in vitro fertilization and the embryo‐transfer (IVF‐ET) cycle.Patients and Methods: The subjects were 72 women who had 96 IVF‐ET cycles and who were examined at Tokyo Medical University Hospital during the period of January 1998 to June 1998 because of mechanical or unexplained infertility for a duration of at least 2 years. Serum samples were collected from all patients during treatment cycles, and serum PPI4 concentrations were measured by a newly established enzyme‐linked immunosorbent assay (ELISA).Results: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0.01). PP14 concentrations were higher in patients with endometria that exhibited homogenous patterns and that were more than 7 mm thicker than in other patients, as determined by ultrasound on the day of oocyte collection (p < 0.005). The pregnancy rates of patients with homogeneous patterns were lower than those of patients showing a trilaminar pattern. No pregnancies were observed when serum PP14 concentrations were greater than 6.85 U/l on the day of oocyte collection.Conclusion: PP14 might be a useful marker for human endometrial receptivity to predict the outcome of IVF‐ET cycles.