6-bromo-3-phenyl-4h-1,2,4-benzothiadiazine-1,1-dioxide | 1193389-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-bromo-3-phenyl-4h-1,2,4-benzothiadiazine-1,1-dioxide
• 英文别名: 6-Bromo-3-phenyl-4H-1$L^{6},2,4-benzothiadiazine-1,1-dione；6-bromo-3-phenyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• CAS: 1193389-22-8
• 化学式: C₁₃H₉BrN₂O₂S
• mdl: MFCD12913061
• 分子量: 337.197
• InChiKey: QWPCCDGUSSQXTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-amino(phenyl)methylene-2,4-dibromo-1-benzenesulfonamide 在 copper(l) iodide 、 potassium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以98%的产率得到6-bromo-3-phenyl-4h-1,2,4-benzothiadiazine-1,1-dioxide
  参考文献：
  名称：

  Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides

  摘要：

  [image omitted] o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives was prepared.

  DOI：

  10.1080/00397911.2010.494815

文献信息

• Facile Synthesis of 4<i>H</i>-1,2,4-Benzothiadiazine-1,1-dioxides
  作者：Artem Cherepakha、Vladimir O. Kovtunenko、Andrey Tolmachev、Oleg Lukin、Konstantin G. Nazarenko

  DOI：10.1080/00397911.2010.494815

  日期：2011.7.1

  [image omitted] o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives was prepared.