2-(6-Methoxynaphthalen-2-yl)propane-1,1-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(6-Methoxynaphthalen-2-yl)propane-1,1-diol
• 化学式: C₁₄H₁₆O₃
• 分子量: 232.27
• InChiKey: BBQFMEWQIWJRIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SOLVENT SYSTEM OF HARDLY SOLUBLE DRUG WITH IMPROVED DISSOLUTION RATE
  申请人：Kim Jae-Hwan

  公开号：US20090318558A1

  公开（公告）日：2009-12-24

  The present invention relates to a solvent system with improved disintegration degree and dissolution ratio of a hardly soluble drug by highly concentrating the drug through partial ionization, and by establishing optimal conditions for enhancing bioavailability of the drug, such as the co-relation between the acid drug and the accompanied components, ionization degree of a solvent system, use of an appropriate cation acceptor, water content, selection of optimal mixing ratio of the respective components and use of specific surfactants, and to a pharmaceutical preparation comprising the same. The solvent system of the invention has advantages in that it can enhance bioavailability by improving the disintegration degree and dissolution ratio of a hardly soluble drug and also provide a capsule with a sufficiently small volume to permit easy swallowing.