Hydron;8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Hydron;8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;dichloride
• 化学式: C22H33Cl2N3O3
• 分子量: 458.4
• InChiKey: NIBOMXUDFLRHRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• G-PROTEIN-CONJUGATED RECEPTOR HAVING ALTERED LIGAND AFFINITY, AND USE THEREOF
  申请人：Pharmacome LLC

  公开号：EP2154154A1

  公开（公告）日：2010-02-17

  A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified.

  通过将 G 蛋白偶联受体与由 SEQ ID NO: 1 的氨基酸序列组成的多肽结合，提供了一种具有改良配体亲和力的改良 G 蛋白偶联受体（GPCR）。此外，还可使用表达了经修饰 GPCR 的转化体来筛选经修饰 GPCR 的激动剂或拮抗剂。这样就有可能提供一种技术，用于分析许多实体尚未明确的假定 GPCR 的功能。
• G-protein-conjugated receptor having altered ligand affinity, and use thereof
  申请人：Muramatsu Ikunobu

  公开号：US20100120068A1

  公开（公告）日：2010-05-13

  A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified.
• Methods of Suppressing Appetite by the Administration of Antagonists of the Serotonin HTR1a or HTR2b Receptors or Inhibitors of TPH2
  申请人：Karsenty Gerard

  公开号：US20120115778A1

  公开（公告）日：2012-05-10

  Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.
• US8173378B2
  申请人：——

  公开号：US8173378B2

  公开（公告）日：2012-05-08
• [EN] METHODS OF SUPPRESSING APPETITE BY THE ADMINISTRATION OF ANTAGONISTS OF THE SEROTONIN HTR1a or HTR2b RECEPTORS OR INHIBITORS OF TPH2<br/>[FR] PROCÉDÉS DE SUPPRESSION DE L'APPÉTIT PAR L'ADMINISTRATION D'ANTAGONISTES DES RÉCEPTEURS HTR1A OU HTR2B DE LA SÉROTONINE OU D'INHIBITEURS DE TPH2
  申请人：UNIV COLUMBIA

  公开号：WO2011009012A1

  公开（公告）日：2011-01-20

  Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.