N'-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-ylmethyl)-N,N-dimethyl-hydrazine | 142634-59-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N'-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-ylmethyl)-N,N-dimethyl-hydrazine
• 英文别名: 2-[[(4S,5S)-1,3-dimethyl-4,5-diphenylimidazolidin-2-yl]methyl]-1,1-dimethylhydrazine
• CAS: 142634-59-1
• 化学式: C₂₀H₂₈N₄
• 分子量: 324.469
• InChiKey: BKIPXOBTVMVVOA-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  magnesium,2-methylpropane,bromide 、 以 乙醚 、 甲苯 为溶剂， 反应 2.0h， 以20%的产率得到N'-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-ylmethyl)-N,N-dimethyl-hydrazine
  参考文献：
  名称：

  Reactivity and diastereoselectivity of Grignard reagents toward the hydrazone functionality in toluene solvent

  摘要：

  Grignard reagents, in toluene solvent, display a strongly increased reactivity toward the hydrazone functionality. With the chiral synthon 1, a highly diastereoselective addition occurs, through chelation control, whereas with pyrazolines 4 and 9 only the d,l diastereomer is formed, leading to a very short synthesis of 1,3-diphenyl-1,3-diaminopropane (11).

  DOI：

  10.1021/jo00043a001

文献信息

• Reactivity and diastereoselectivity of Grignard reagents toward the hydrazone functionality in toluene solvent
  作者：Alex Alexakis、Nathalie Lensen、Jean Philippe Tranchier、Pierre Mangeney

  DOI：10.1021/jo00043a001

  日期：1992.8

  Grignard reagents, in toluene solvent, display a strongly increased reactivity toward the hydrazone functionality. With the chiral synthon 1, a highly diastereoselective addition occurs, through chelation control, whereas with pyrazolines 4 and 9 only the d,l diastereomer is formed, leading to a very short synthesis of 1,3-diphenyl-1,3-diaminopropane (11).