(2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: (2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
• 化学式: C₂₂H₂₄N₂O₉
• 分子量: 460.4
• InChiKey: FYDOORKXBWEKQM-GUQPPTOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  202
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• [EN] CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION<br/>[FR] BACTERICIDES AU CARBAPENEM A ACTIVITE GRAM-NEGATIVE ET PROCEDES D'ELABORATION CORRESPONDANTS
  申请人：FOB SYNTHESIS

  公开号：WO2005123066A1

  公开（公告）日：2005-12-29

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供β-甲基卡巴比那类化合物和制剂，用于治疗细菌感染，并提供了使用这些化合物和/或制剂治疗此类感染的方法。该发明包括向需要此类治疗的宿主施用β-卡巴比那类化合物或其盐和/或前药的有效量。本发明还涉及合成有机化学领域，特别提供了一种改进的合成β-甲基卡巴比那类化合物的方法，这些化合物可用作抗菌剂。
• Carbapenem antibacterials with gram-negative activity and processes for their preparation
  申请人：Choi Woo-Baeg

  公开号：US20060069081A1

  公开（公告）日：2006-03-30

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供了β-甲基头孢菌素类化合物和制药组合物，可用于治疗细菌感染，并提供使用该类化合物和/或组合物治疗此类感染的方法。该发明包括向需要此类治疗的宿主中给予β-头孢菌素类化合物或其盐和/或前药的有效剂量。本发明还属于合成有机化学领域，具体提供了一种改进的β-甲基头孢菌素类化合物合成方法，其可用作抗菌药物。
• Gram-positive carbapenem antibacterials and processes for their preparation
  申请人：Choi Woo-Baeg

  公开号：US20060074070A1

  公开（公告）日：2006-04-06

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供了β-甲基碳青霉烯化合物和制药组合物，可用于治疗细菌感染，并提供了使用这些化合物和/或组合物治疗此类感染的方法。本发明包括向需要此类治疗的宿主施用β-碳青霉烯化合物或盐和/或前药的有效量。本发明还属于合成有机化学领域，特别提供了一种改进的β-甲基碳青霉烯合成方法，其可用作抗菌剂。
• GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION
  申请人：Choi Woo-Baeg

  公开号：US20100075945A1

  公开（公告）日：2010-03-25

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供了β-甲基碳青霉烯化合物和制药组合物，可用于治疗细菌感染，并提供使用这些化合物和/或组合物治疗此类感染的方法。本发明包括向需要此类治疗的宿主投与有效量的碳青霉烯化合物或盐和/或前药。本发明还属于合成有机化学领域，特别提供了一种改进的β-甲基碳青霉烯化合物合成方法，该方法可用作抗菌剂。
• CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION
  申请人：Choi Woo-Baeg

  公开号：US20100160284A1

  公开（公告）日：2010-06-24

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供β-甲基碳青霉烯类化合物和制备这些化合物的药物组合物，用于治疗细菌感染，并提供使用这些化合物和/或组合物治疗此类感染的方法。本发明包括向需要此类治疗的宿主施用β-甲基碳青霉烯类化合物或其盐和/或前药的有效量。本发明还属于合成有机化学领域，具体提供了一种改进的β-甲基碳青霉烯合成方法，这些化合物可用作抗菌剂。