N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide
• 化学式: C₂₉H₃₉N₅O₈
• 分子量: 585.6
• InChiKey: ZXGBRIBPJBHLMO-SBMFAFPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  206
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2015051241A1

  公开（公告）日：2015-04-09

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本发明描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及用于治疗与激酶活性相关的疾病和状况的化合物、药物组合物和方法，包括PI3激酶活性。
• [EN] HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE TROUBLES MÉDIÉS PAR PI3K-GAMMA
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2015143012A1

  公开（公告）日：2015-09-24

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本文描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和状况的治疗方法，包括PI3激酶活性的化合物、药物组合物和治疗方法。
• [EN] PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS<br/>[FR] ESTERS PHOSPHORIQUES D'INHIBITEURS DE GYRASES ET DE TOPOISOMÉRASES
  申请人：VERTEX PHARMA

  公开号：WO2012177707A1

  公开（公告）日：2012-12-27

  The present invention relates to phosphate esters of compounds that inhibit bacterial gyrase and/or Topoisomerase IV and pharmaceutical compositions thereof. These phosphate esters are useful for treating bacterial infections.

  本发明涉及抑制细菌旋转酶和/或拓扑异构酶IV的化合物的磷酸酯以及其药物组成物。这些磷酸酯对治疗细菌感染具有用途。
• PENEM PRODRUG
  申请人：Brighty Katherine Elizabeth

  公开号：US20080125408A1

  公开（公告）日：2008-05-29

  The invention relates to prodrugs of sulopenem of formula (I): wherein R 1 is —(C 2 -C 8 )alkyl, or a solvate or hydrate thereof. The invention also relates to the preparation, formulation, and use of the prodrugs of sulopenem to treat a disorder such as an infection in a patient in need thereof.

  该发明涉及式(I)的舒洛佩内酯前药，其中R1为—(C2-C8)烷基，或其溶剂合物或水合物。该发明还涉及制备、配方和使用舒洛佩内酯前药来治疗患有感染等疾病的患者。
• Pyrrolic derivatives, processes for preparing the same and their uses as antibiotics
  申请人：Université Joseph Fourier

  公开号：EP2626357A1

  公开（公告）日：2013-08-14

  The present invention relates to pyrrolic derivatives processes for their preparation, and their use as new antibacterial drugs.

  本发明涉及吡咯酮衍生物的制备过程，以及将其用作新型抗菌药物的用途。