(3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并噻嗪类
• 英文名称: (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
• 化学式: C₁₃H₁₁N₃O₄S₂
• 分子量: 337.4
• InChiKey: WZWYJBNHTWCXIM-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NITROXIDE MODIFIED NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF IN THE TREATMENT AND PREVENTION OF DISEASES OR DISORDERS
  申请人：Wink David A.

  公开号：US20120263650A1

  公开（公告）日：2012-10-18

  Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof: in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

  揭示了具有以下结构式（I）的硝基氧自由基修饰的NSAID化合物或其药用盐或对映体：其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11和n在此处被定义，并其药物组合物。进一步揭示了一种治疗或预防各种疾病的方法，如炎症、癌症、糖尿病、心血管疾病、体重增加、息肉和/或慢性疼痛，在患者中包括给予化合物或结构式（I）的药用盐或对映体的有效量。还提供了一种在动物体内成像化合物或结构式（I）的药用盐或对映体的方法。
• Nitroxide radicals for the treatment of diseases of the respiratory tract
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：US10441568B2

  公开（公告）日：2019-10-15

  Cyclic nitroxide compounds including, but not limited to, compounds having the general formula I: wherein the dashed line and R1-R8 are as defined herein, are disclosed herein for use in treating diseases and disorders of the respiratory tract and/or respiratory tract remodeling.

  环状亚硝基化合物，包括但不限于具有通式 I 的化合物： 其中虚线和 R1-R8 如本文所定义，本文公开的这些化合物用于治疗呼吸道和/或呼吸道重塑的疾病和失调。
• NITROXIDE RADICALS FOR THE TREATMENT OF DISEASES OF THE RESPIRATORY TRACT
  申请人：Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：EP3273956A1

  公开（公告）日：2018-01-31
• NITROXYL (HNO) RELEASING COMPOUNDS AND USES THEREOF IN TREATING DISEASES
  申请人：Miranda Katrina M.

  公开号：US20130065863A1

  公开（公告）日：2013-03-14

  Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R 1 , R 2 , R 3 , and R 4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).
• Synergistic Combination Comprising Avermectins and a NSAID for Tumor Inhibition
  申请人：Ectin Research AB

  公开号：US20140371164A1

  公开（公告）日：2014-12-18

  The present invention includes a composition comprising an effective amount of an avermectin compound, and an effective amount of an imidazole antifungal compound, and/or an effective amount of non-steroidal anti-inflammatory drug (NSAID) or suitable pharmaceutically acceptable salts thereof, for use in the inhibition of tumor growth and treating urothelial, colorectal, prostate and/or breast cancers. Furthermore, the invention includes a method of inhibiting tumor growth and treating said cancers comprising administering to a subject in need thereof an effective amount of said composition.