(2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydron;chloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydron;chloride
• 化学式: C22H24Cl2N2O8
• 分子量: 515.3
• InChiKey: RRXOSDMYCQSQHB-MRYPCDLHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  182
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Methods for detecting and/or predicting age-related macular degeneration and/or Alzheimer's disease
  申请人：University of Maryland, Baltimore

  公开号：US11253614B2

  公开（公告）日：2022-02-22

  The present invention provides for the use of hydroxyapatite-selective fluorescent dyes in combination with fluorescence lifetime imaging to detect any hydroxyapatite spherules or hydroxyapatite deposits in the retina tissue of a subject, including the peripheral or macula tissue, wherein the hydroxyapatite spherules or hydroxyapatite deposits initiate or support the growth of sub-RPE deposits and correlates with age-related macular degeneration and/or Alzheimer's disease.

  本发明提供了羟基磷灰石选择性荧光染料与荧光寿命成像相结合的使用方法，以检测受试者视网膜组织（包括周边或黄斑组织）中的任何羟基磷灰石球或羟基磷灰石沉积物，其中羟基磷灰石球或羟基磷灰石沉积物启动或支持RPE下沉积物的生长，并与年龄相关性黄斑变性和/或阿尔茨海默病相关。
• METHODS FOR DETECTING AND/OR PREDICTING AGE-RELATED MACULAR DEGENERATION AND/OR ALZHEIMER'S DISEASE
  申请人：University of Maryland, Baltimore

  公开号：EP3504554A1

  公开（公告）日：2019-07-03
• PHARMACEUTICAL COMPOSITION FOR IMPROVING ORAL HYGIENE AND METHODS THEREOF
  申请人：EIREW Gary H.

  公开号：US20090035229A1

  公开（公告）日：2009-02-05

  An aqueous based pharmaceutical composition for use as a oral hygienic treatment is described. The composition contains a pharmaceutically effective amount of a tetracycline-based antibiotic; a water-soluble calcium salt that aids in solubilizing the tetracycline-based antibiotic; a thickener; a pH adjustment agent; an antifoaming agent; an excipient; a surfactant; a preservative; and a flavoring agent. A method of making the aqueous based pharmaceutical composition includes the steps of adjusting, defoaming, dispensing, dispersing, dissolving, flavoring, heating, minimizing, pouring, solubilizing, suspending, and sweetening. A method of using the aqueous based pharmaceutical composition is also disclosed which includes the steps of expectorating, gargling, obtaining, pouring, receiving, and swishing.
• USE OF ANAEROBIC DIGESTION TO DESTROY ANTIBIOTICS IN ORGANIC WASTE
  申请人：Himark bioGas Inc.

  公开号：US20150125921A1

  公开（公告）日：2015-05-07

  The invention relates to systems and methods for using the anaerobic digestion (AD) process, especially thermophilic anaerobic digestion (TAD), to destroy biohazard materials including antibiotics.
• COMPOSITIONS AND METHODS FOR TREATING HUANGLONGBING DISEASE IN CITRUS
  申请人：NEW LIFE CROP SCIENCES LLC

  公开号：US20210144998A1

  公开（公告）日：2021-05-20

  The subject invention pertains to compositions and methods for controlling and/or treating citrus greening in citrus plants, such as orange trees, grapefruit trees, lime trees, lemon trees and the like. The compositions include fertilizers and liquid formulations.