S1P

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: S1P
• 英文别名: [(E,2R,3S)-2-azaniumyl-3-hydroxyoctadec-4-enyl] hydrogen phosphate
• 化学式: C₁₈H₃₈NO₅P
• 分子量: 379.477
• InChiKey: DUYSYHSSBDVJSM-MCXRAWCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tert-butyl N-[(E,2R,3S)-1-dimethoxyphosphoryloxy-3-hydroxyoctadec-4-en-2-yl]carbamate 在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 S1P
  参考文献：
  名称：

  Syntheses of sphingosine-1-phosphate stereoisomers and analogues and Their interaction with EDG receptors

  摘要：

  Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00893-4

文献信息

• USE OF SPHINGOID LONG CHAIN BASES AND THEIR ANALOGS IN TREATING AND PREVENTING BACTERIAL INFECTIONS
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20150258043A1

  公开（公告）日：2015-09-17

  Methods of preventing or treating bacterial infections, including but not limited to Pseudomonas aeruginosa infections, by administering sphingoid long chain bases (LCB) are provided. The invention further relates to the use of sphingoid long chain bases, or pharmaceutical composition comprising same, for the treatment of lung diseases or disorders such as cystic fibrosis and chronic obstructive pulmonary disease.
• COMPOSITIONS AND METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
  申请人：GAVISH-GALILEE BIO APPLICATIONS LTD.

  公开号：US20200308100A1

  公开（公告）日：2020-10-01

  The present invention relates to lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) or derivatives thereof for use in the treatment of atherosclerotic cardiovascular disease, and further provides particular such lyso-DGTS derivatives.