1-(2-hydroxy-1-naphthyl)acetone | 58805-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-hydroxy-1-naphthyl)acetone
• 英文别名: 1-(2-Hydroxy-1-naphthyl)-propan-2-on；(2-hydroxy-[1]naphthyl)-acetone；(2-Hydroxy-[1]naphthyl)-aceton；2-Hydroxyl-1-naphthyl acetone；1-(2-hydroxynaphthalen-1-yl)propan-2-one
• CAS: 58805-24-6
• 化学式: C₁₃H₁₂O₂
• 分子量: 200.237
• InChiKey: ICQQOGBBAYXDNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-hydroxy-1-naphthyl)acetone 生成 2-Hydroxy-2-methylnaphtho<2.1-b>furan-1(2H)-on
  参考文献：
  名称：

  CARNDUFF J.; MARKS R. B., J. CHEM. RES. SYNOP., 1977, NO 8, 201

  摘要：

  DOI：
• 作为产物：
  描述：

  2-bromo-1-methylbenzo[f]chromen-3-one 以78%的产率得到
  参考文献：
  名称：

  CARNDUFF J.; MARKS R. B., J. CHEM. RES. SYNOP., 1977, NO 8, 201

  摘要：

  DOI：

文献信息

• Expeditious synthesis of dihydronaphthofurans utilising 1,2-dioxines and stabilised phosphorus ylides
  作者：Thomas D. Haselgrove、Martyn Jevric、Dennis K. Taylor、Edward R.T. Tiekink

  DOI：10.1016/s0040-4020(99)00919-9

  日期：1999.12

  A new practical synthesis of functionalised 1,2-dihydronaphtho[2,1-b]furans from substituted 2,4a-dihydronaphtho[2,1-c][1,2]dioxines and stabilised phosphorus ylides is described. Functionalised γ-hydroxy enones and their isomeric hemiacetals are key intermediates.

  官能化的1,2-二氢萘并[2,1-的新型实用的合成b ]呋喃从取代的2,4-一个-dihydronaphtho [2,1- c ^ ] [1,2]二喔星和稳定的磷内鎓盐进行说明。功能化的γ-羟基烯酮及其异构半缩醛是关键中间体。
• DDQ induced oxidative cyclisations of 1,2-dihydronaptho[2,1-b]furans
  作者：Martyn Jevric、Dennis K. Taylor、Ben W. Greatrex、Edward R.T. Tiekink

  DOI：10.1016/j.tet.2004.12.010

  日期：2005.2

  The DDQ mediated oxidative cyclisation reactions of a series of dihydronaptho[2,1-b]furans were examined. In the presence of an acid catalyst, the reaction yielded polycyclic ethers and lactones in good to excellent yields. (C) 2005 Elsevier Ltd. All rights reserved.
• 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS
  申请人：Pharmagene Laboratories Ltd

  公开号：EP1474140A1

  公开（公告）日：2004-11-10
• [EN] 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS<br/>[FR] 2-OXAZOLAMINES ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR 5-HT2B
  申请人：PHARMAGENE LAB LTD

  公开号：WO2003068226A1

  公开（公告）日：2003-08-21

  The present invention relates to compounds of formula (I): wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either:(i) independently selected from H, R, R', SO2R, C(=O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.