N-[(E)-1-(4-aminophenyl)ethylideneamino]furan-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: N-[(E)-1-(4-aminophenyl)ethylideneamino]furan-2-carboxamide
• 化学式: C₁₃H₁₃N₃O₂
• 分子量: 243.26
• InChiKey: PBCJNNZVLXDHCR-OQLLNIDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Systems pharmacology for treating ocular disorders
  申请人：Case Western Reserve University

  公开号：US10117868B2

  公开（公告）日：2018-11-06

  A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.

  一种治疗受试者眼部疾病的方法包括向受试者施用亚治疗量的两种或两种以上抑制和/或阻断受试者眼部细胞中 Gs 或 Gq 蛋白偶联受体或 Gs 或 Gq 信号级联激活的制剂，和/或激活 Gi- 蛋白偶联受体，这是由光诱导全反式视网膜生成诱导或触发的。
• Compounds and methods of treating ocular disorders
  申请人：Case Western Reserve University

  公开号：US10208049B2

  公开（公告）日：2019-02-19

  A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.

  一种治疗与视网膜中全反式视网膜清除异常有关的受试者眼部疾病的方法，该方法包括向受试者施用治疗有效量的式伯胺化合物： 其中 R1 是脂肪族和/或芳香族化合物。
• Compositions and methods of treating diabetic retinopathy
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US10272106B2

  公开（公告）日：2019-04-30

  A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.

  一种治疗糖尿病视网膜病变受试者的方法包括向受试者施用一种或多种治疗有效量的制剂，这些制剂可作为活性醛的捕获剂和/或抑制糖尿病诱导的超氧化物生成和由 GPCR 信号通路调节的毛细血管变性。
• GAMMA AMINOACIDS FOR TREATING OCULAR DISORDERS
  申请人：Case Western Reserve University

  公开号：EP2509596B1

  公开（公告）日：2019-08-28
• COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  申请人：Palczewski Krzysztof

  公开号：US20120295895A1

  公开（公告）日：2012-11-22

  A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R 1 is an aliphatic and/or aromatic compound.