(E)-3-(3-hydroxy-6-oxo-xanthen-9-yl)prop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (E)-3-(3-hydroxy-6-oxo-xanthen-9-yl)prop-2-enoic acid
• 英文别名: (E)-3-(3-hydroxy-6-oxoxanthen-9-yl)prop-2-enoic acid
• 化学式: C₁₆H₁₀O₅
• 分子量: 282.25
• InChiKey: GKEOQSRVZYLDTJ-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
  申请人：University of Rochester

  公开号：EP2147310A2

  公开（公告）日：2010-01-27
• Compositions and Methods for Inhibiting G Protein Signaling
  申请人：University of Rochester

  公开号：US20130116313A1

  公开（公告）日：2013-05-09

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.
• US8748480B2
  申请人：——

  公开号：US8748480B2

  公开（公告）日：2014-06-10
• US8975259B2
  申请人：——

  公开号：US8975259B2

  公开（公告）日：2015-03-10
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INHIBER LA SIGNALISATION DE LA PROTÉINE G
  申请人：UNIV ROCHESTER

  公开号：WO2009020677A2

  公开（公告）日：2009-02-12

  A method of identifying an agent which binds to at least one amino acid residue of the protein interaction site of G-protein beta subunit composes contacting a G protein beta subunit with a test agent in the presences of a peptide that binds at least one amino acid residue of the protein interaction site of the beta subunit and determining whether the agent inhibits the binding of the peptide.