7-hydroxy-8-methyl-3-phenoxy-4H-chromen-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-hydroxy-8-methyl-3-phenoxy-4H-chromen-4-one
• 英文别名: 7-hydroxy-8-methyl-3-phenoxychromen-4-one
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.26
• InChiKey: LKXDFZSJWKPGBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• THERMOSTABILIZATION OF PROTEINS
  申请人：The Trustees Of Columbia University In The City Of New York

  公开号：EP2170373B1

  公开（公告）日：2014-07-02
• US8637009B2
  申请人：——

  公开号：US8637009B2

  公开（公告）日：2014-01-28
• US9526786B2
  申请人：——

  公开号：US9526786B2

  公开（公告）日：2016-12-27
• [EN] THERMOSTABILIZATION OF PROTEINS<br/>[FR] THERMOSTABILISATION DE PROTÉINES
  申请人：UNIV COLUMBIA

  公开号：WO2009009669A2

  公开（公告）日：2009-01-15

  Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.