(2E)-2-cyano-2-(3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)-N-(2,4-dimethylphenyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (2E)-2-cyano-2-(3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)-N-(2,4-dimethylphenyl)acetamide
• 化学式: C₂₂H₂₃N₃O
• 分子量: 345.4
• InChiKey: GOKJYAGJIKHEPU-CZIZESTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Cell differntiation inhibiting agent, cell culture method using the same, culture medium, and cultured cell line
  申请人：Miyabayashi Tomoyuki

  公开号：US20050153941A1

  公开（公告）日：2005-07-14

  The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent.

  本发明的目的是提供一种抑制分化的药剂，该药剂允许在不使用任何饲养细胞的情况下以未分化状态培养干细胞或胚胎干细胞，以及使用相同药剂进行培养的方法，使用相同药剂的细胞培养液，以及使用这种抑制分化药剂进行培养制备的细胞。本发明提供了一种包含低分子量化合物，特别是四氢异喹啉衍生物作为活性成分的抑制分化药剂；一种安全地在大规模中以未分化状态培养干细胞而无需饲养细胞的方法，其中包括使用四氢异喹啉衍生物培养干细胞；一种包含四氢异喹啉衍生物的干细胞培养液；以及通过使用四氢异喹啉衍生物作为抑制分化药剂进行培养获得的细胞。
• CELL DIFFERENTIATION SUPPRESSING AGENT, METHOD OF CULTURING CELLS USING THE SAME, CULTURE SOLUTION, AND CULTURED CELL LINE
  申请人：Miyabayashi Tomoyuki

  公开号：US20090155906A1

  公开（公告）日：2009-06-18

  The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent.

  本发明的目的是提供一种抑制分化的剂，该剂使得干细胞或胚胎干细胞可以在未分化状态下培养，而无需使用任何饲养细胞，以及使用该剂的培养方法、使用该剂的细胞培养液和使用该抑制分化剂培养制备的细胞。本发明提供了一种抑制分化的剂，其包括低分子量化合物，特别是四氢异喹啉衍生物，作为活性成分；一种安全地大规模培养未分化状态的干细胞的方法，该方法通过使用四氢异喹啉衍生物来培养干细胞而不使用饲养细胞；一种包含四氢异喹啉衍生物的干细胞培养液；以及通过使用四氢异喹啉衍生物作为抑制分化剂进行培养获得的细胞。
• SERUM-FREE EXPANSION OF CELLS IN CULTURE
  申请人：Choongwae Pharma Corporation

  公开号：EP1960777B1

  公开（公告）日：2009-10-21
• Serum-free expansion of cells in culture
  申请人：Kahn Michael

  公开号：US20070128669A1

  公开（公告）日：2007-06-07

  Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
• US8883504B2
  申请人：——

  公开号：US8883504B2

  公开（公告）日：2014-11-11