2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₂₀H₂₂O₈
• 分子量: 390.4
• InChiKey: HSTZMXCBWJGKHG-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  140
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY
  申请人：Espin De Gea Juan Carlos

  公开号：US20120309699A1

  公开（公告）日：2012-12-06

  Compounds of general formula (I) for the treatment of inflammatory processes involved in numerous diseases such as intestinal inflammatory diseases. The invention moreover refers to compounds included within such general formula and to the procedure of the obtainment thereof.

  通用公式（I）的化合物用于治疗涉及多种疾病的炎症过程，如肠道炎症性疾病。此外，该发明还涉及包含在这种通用公式内的化合物以及其获得方法。
• METHOD FOR PRODUCING MODIFIED RESVERATROL
  申请人：EVOLVA SA

  公开号：US20160215306A1

  公开（公告）日：2016-07-28

  Methods for producing glycosylated and methylated resveratrol in a genetically engineered cell, by bioconversion, and in vitro are disclosed herein.

  本文揭示了通过基因工程细胞、生物转化和体外方法生产糖基化和甲基化白藜芦醇的方法。
• Formulations comprising PIECID and RESVERATROL able to prevent and inhibit lipid peroxidation
  申请人：Glures S.R.L.

  公开号：EP2087894A1

  公开（公告）日：2009-08-12

  The antioxidant properties of piceid and resveratrol are reported, these, by virtue of their physicochemical characteristics, being able to prevent and inhibit lipid peroxidation because of their lipophilicity and their effectiveness against a wide range of free radicals and radical initiators.

  据报道，piceid 和白藜芦醇具有抗氧化特性，由于其亲脂性，能够防止和抑制脂质过氧化，并能有效对抗各种自由基和自由基引发剂。
• Fluid compositions comprising polyphenols and methods for making and packaging the same
  申请人：IdeaMed LLC

  公开号：EP2172118A2

  公开（公告）日：2010-04-07

  A beverage package for a beverage comprising an aqueous solution and a polyphenol containing compound comprises a reservoir capable of isolating the polyphenol containing compound from the aqueous solution until the time of consumption.

  一种饮料包装，用于盛放包含水溶液和含多酚类化合物的饮料，该饮料包装包括一个储液器，能够将含多酚类化合物从水溶液中分离出来，直到饮用为止。
• Combination of bezafibrate and of resveratrol or resveratrol derivatives for the treatment and prevention of diseases involving a mitochondrial energy dysfunction
  申请人：Institut National De La Santé Et De La Recherche Médicale (INSERM)

  公开号：US10376484B2

  公开（公告）日：2019-08-13

  The present invention relates to the combined use of bezafibrate and of resveratrol or resveratrol derivatives for the treatment of diseases involving a mitochondrial energy dysfunction, and also to a pharmaceutical kit comprising both bezafibrate and resveratrol or resveratrol derivatives. The combination is more particularly used in the treatment of moderate defects of β-oxidation of long-chain fatty acids or of the respiratory chain of mitochondria.

  本发明涉及联合使用贝扎贝特和白藜芦醇或白藜芦醇衍生物治疗涉及线粒体能量功能障碍的疾病，还涉及一种包含贝扎贝特和白藜芦醇或白藜芦醇衍生物的药物试剂盒。该组合药剂尤其可用于治疗长链脂肪酸β-氧化或线粒体呼吸链的中度缺陷。