(4aR,5R,9bR)-1-Methyl-5-o-tolyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one | 88687-32-5

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基四氢萘木脂素
• 英文名称: (4aR,5R,9bR)-1-Methyl-5-o-tolyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one
• CAS: 88687-32-5
• 化学式: C₂₀H₂₁NO
• 分子量: 291.393
• InChiKey: JEGYUZLWQFRWDR-RLLQIKCJSA-N

反应信息

• 作为反应物：
  描述：

  (4aR,5R,9bR)-1-Methyl-5-o-tolyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one 在 lithium aluminium tetrahydride 作用下， 生成 (4aR,5R,9bR)-1-Methyl-5-o-tolyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridine
  参考文献：
  名称：

  2,3,4,4a,5,9b-Hexahydro-1H-indeno[1,2-b]pyridines: potential antidepressants

  摘要：

  The synthesis of various diastereoisomeric H4a,H5-cis,H4a,H9b-cis- and H4a,H5-trans,H4a,H9b-cis-2,3,4,4a,5,9b-hexahydro -1H-indeno[1,2-b]pyridines is described, as well as the evaluation of their antidepressant potency. Elucidation of structure-activity relationships revealed the H4a,H5-trans compounds as being by far the more active of the two series of diastereoisomers. Pharmacological and biochemical data suggest that these compounds are potential antidepressants with central stimulating properties, which are characterized by strong norepinephrine and dopamine reuptake inhibition.

  DOI：

  10.1021/jm00370a004