1-{(2R,3R,4R,5R)-3-Allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-prop-1-ynyl-1H-pyrimidine-2,4-dione | 148504-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-{(2R,3R,4R,5R)-3-Allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-prop-1-ynyl-1H-pyrimidine-2,4-dione
• CAS: 148504-72-7
• 化学式: C₃₆H₃₆N₂O₈
• 分子量: 624.69
• InChiKey: MOIMMBSZAKFVIV-UKNNOAMWSA-N

物化性质

• 密度：
  1.32±0.1 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-5-prop-1-ynyl-1H-pyrimidine-2,4-dione 在 四氢呋喃 、 吡啶 、 四丁基氟化铵 作用下， 以 乙酸乙酯 为溶剂， 反应 19.0h， 生成 1-{(2R,3R,4R,5R)-3-Allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-prop-1-ynyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Oligonucleotides derived from 5-(1-propynyl)-2′-O-allyl-uridine and 5-(1-propynyl)-2′-O-allyl-cytidine: Synthesis and RNA duplex formation

  摘要：

  The protected nucleoside analogs of 5-(1-propynyl)-2'-O-allyl-uridine and 5-(1-propynyl)-2'-O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA.

  DOI：

  10.1016/s0040-4039(00)77476-4