Acetic acid (2R,3R,4R,5R,6R)-4-acetoxy-5-acetylamino-6-(6-benzyloxycarbonylamino-hexyloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester | 791823-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Acetic acid (2R,3R,4R,5R,6R)-4-acetoxy-5-acetylamino-6-(6-benzyloxycarbonylamino-hexyloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester
• CAS: 791823-92-2
• 化学式: C₄₇H₅₆N₂O₁₂
• 分子量: 840.968
• InChiKey: LMJCNYXZZGZANV-XVQIYQHQSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (2R,3R,4R,5R,6R)-4-acetoxy-5-acetylamino-6-(6-benzyloxycarbonylamino-hexyloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester 在 苯磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.03h， 生成 (6-(benzyloxycarbonylamino)hexyl) 2-acetamido-3,4-di-O-acetyl-2-deoxy-β-D-galactopyranoside 、 (6-(benzyloxycarbonylamino)hexyl) 2-acetamido-3,4-di-O-acetyl-2-deoxy-α-D-galactopyranoside
  参考文献：
  名称：

  Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize Both Streptococcus pneumoniae and Neisseria meningitidis:  A Potential Multitarget Vaccine against Respiratory Infections

  摘要：

  Phosphoryleholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GaINAc-ChoP-specific antibodies which recognized Chol? on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.

  DOI：

  10.1021/jm040783p
• 作为产物：
  描述：

  (6-(benzyloxycarbonyl)hexyl) 2-acetamido-3,4,6-tri-O-acetyl-2-doexy-D-galactopyranoside 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 4.17h， 生成 Acetic acid (2R,3R,4R,5R,6R)-4-acetoxy-5-acetylamino-6-(6-benzyloxycarbonylamino-hexyloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize Both Streptococcus pneumoniae and Neisseria meningitidis:  A Potential Multitarget Vaccine against Respiratory Infections

  摘要：

  Phosphoryleholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GaINAc-ChoP-specific antibodies which recognized Chol? on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.

  DOI：

  10.1021/jm040783p