| 1163725-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1163725-73-2
• 化学式: C₄₉H₅₅N₅O₁₁S
• 分子量: 922.069
• InChiKey: CWUPSEDBXXRLDN-PNIYFJJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  66.0
• 可旋转键数：
  20.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  199.75
• 氢给体数：
  4.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  、 双(二异丙基氨基)(2-氰基乙氧基)膦 在 三氟乙酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以1.24 g的产率得到
  参考文献：
  名称：

  A probe for detection of G-rich target strands through fluorescence quenching

  摘要：

  A modified fluorescent probe U(F)AA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3'-O-(N,N'-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3'-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.

  DOI：

  10.1134/s1068162009010087
• 作为产物：
  描述：

  、 4,4'-双甲氧基三苯甲基氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  A probe for detection of G-rich target strands through fluorescence quenching

  摘要：

  A modified fluorescent probe U(F)AA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3'-O-(N,N'-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3'-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.

  DOI：

  10.1134/s1068162009010087