4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl acetate | 1152731-52-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl acetate
• CAS: 1152731-52-6
• 化学式: C₅₀H₄₈N₆O₈
• 分子量: 860.967
• InChiKey: MDVOJYVFLGTKBM-YAYCHGGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.65
• 重原子数：
  64.0
• 可旋转键数：
  14.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  148.39
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl acetate 在 三氯乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以27%的产率得到4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-yl acetate
  参考文献：
  名称：

  Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities

  摘要：

  We have synthesized a series of 5'-phosphorylated and 5'-cytidylyl-(3'-5')-cytidylyl-(3'-5')-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.006
• 作为产物：
  描述：

  乙酸酐 、 (9H-fluoren-9-yl)methyl 2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-ylcarbamate 在 吡啶 作用下， 以61%的产率得到4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl acetate
  参考文献：
  名称：

  Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities

  摘要：

  We have synthesized a series of 5'-phosphorylated and 5'-cytidylyl-(3'-5')-cytidylyl-(3'-5')-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.006