5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside | 790710-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside
• CAS: 790710-39-3
• 化学式: C₄₆H₃₈O₅
• 分子量: 670.805
• InChiKey: FPNCLWCAUIKZHB-WTQYMLSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.95
• 重原子数：
  51.0
• 可旋转键数：
  9.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α/β-D-2'-deoxyriboside-3'-O-(cyanoethyl-N,N-diisopropylamino)phosphoramidite
  参考文献：
  名称：

  Modified DNA Analogues That Sense Light Exposure with Color Changes

  摘要：

  We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.

  DOI：

  10.1021/ja046910o
• 作为产物：
  描述：

  6-benzo[a]pyrene-1'-α/β-D-2'-deoxyriboside-3',5'-di(p-toluoyl) ester 在 吡啶 、 甲醇 、 sodium methylate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside
  参考文献：
  名称：

  Modified DNA Analogues That Sense Light Exposure with Color Changes

  摘要：

  We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.

  DOI：

  10.1021/ja046910o