6-hydroxy-4-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-napthaldehyde

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基四氢萘木脂素
• 英文名称: 6-hydroxy-4-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-napthaldehyde
• 英文别名: 6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaldehyde；7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-6-methoxy-1,2-dihydro-3-naphthaldehyde；6-Hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaldehyde；6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-3,4-dihydronaphthalene-2-carbaldehyde
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: PATMJUOZIPKVAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-hydroxy-4-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-napthaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以100%的产率得到9,9'-Dihydroxy-guaja-cyclolign-7'-en
  参考文献：
  名称：

  Singh; Chitra; Singh, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2005, vol. 44, # 6, p. 1288 - 1290

  摘要：

  DOI：

文献信息

• ARYL DIHYDRO-NAPHTHALENE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS AKT INHIBITOR FOR THE PREVENTION AND TREATMENT OF CANCER
  申请人：Central South University

  公开号：EP1972611A1

  公开（公告）日：2008-09-24

  The present invention discloses 9 Aryldihydronnaphthalenes that inhibit Akt activation. The invention also provides compositions composing such inhibitory compounds and methods of inhibiting Akt activity by administrating the compounds to patients with cancer.

  本发明揭示了9种抑制Akt激活的芳基二氢萘类化合物。该发明还提供了包含这些抑制化合物的组合物和通过将这些化合物用于癌症患者来抑制Akt活性的方法。