5'-O-(monomethoxytriphenylmethyl)-5-ethyl-4'-thio-2'-deoxyuridine | 175470-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-(monomethoxytriphenylmethyl)-5-ethyl-4'-thio-2'-deoxyuridine
• 英文别名: 5-ethyl-1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]thiolan-2-yl]pyrimidine-2,4-dione
• CAS: 175470-98-1
• 化学式: C₃₁H₃₂N₂O₅S
• 分子量: 544.671
• InChiKey: GLCRGQMKOUQCKH-UPRLRBBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5'-O-(monomethoxytriphenylmethyl)-5-ethyl-4'-thio-2'-deoxyuridine 在 溶剂黄146 作用下， 以 吡啶 为溶剂， 反应 26.0h， 生成 3'-O-acetyl-5-ethyl-4'-thio-2'-deoxyuridine
  参考文献：
  名称：

  Some Reactions of 4′-Thionucleosides and Their Sulfones

  摘要：

  We report interesting and novel reactions of 4'-thionucleosides and their sulfone derivatives when a good leaving group is present in the 5'-position. The results have important implications for the phosphorylation of these nucleoside analogues by standard chemical procedures. Possible mechanisms for these reactions are discussed.

  DOI：

  10.1080/07328319608002376
• 作为产物：
  描述：

  4'-硫代-5-乙基-2'-脱氧尿苷 、 4-甲氧基三苯基氯甲烷 以 吡啶 为溶剂， 反应 18.0h， 以90%的产率得到5'-O-(monomethoxytriphenylmethyl)-5-ethyl-4'-thio-2'-deoxyuridine
  参考文献：
  名称：

  Some Reactions of 4′-Thionucleosides and Their Sulfones

  摘要：

  We report interesting and novel reactions of 4'-thionucleosides and their sulfone derivatives when a good leaving group is present in the 5'-position. The results have important implications for the phosphorylation of these nucleoside analogues by standard chemical procedures. Possible mechanisms for these reactions are discussed.

  DOI：

  10.1080/07328319608002376

文献信息

• Some Reactions of 4′-Thionucleosides and Their Sulfones
  作者：E. Louise Hancox、Richard T. Walker

  DOI：10.1080/07328319608002376

  日期：1996.1

  We report interesting and novel reactions of 4'-thionucleosides and their sulfone derivatives when a good leaving group is present in the 5'-position. The results have important implications for the phosphorylation of these nucleoside analogues by standard chemical procedures. Possible mechanisms for these reactions are discussed.