2,3,6-trimethyl-piperidine | 50402-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,3,6-trimethyl-piperidine
• 英文别名: 2,3,6-Trimethyl-piperidin；2,3,6-trimethylpiperidine
• CAS: 50402-72-7
• 化学式: C₈H₁₇N
• mdl: MFCD19218106
• 分子量: 127.23
• InChiKey: VPTSQBHQXVQANU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 2,3,6-trimethyl-piperidine
  参考文献：
  名称：

  Nasarow; Rudenko, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948, p. 610,620

  摘要：

  DOI：

文献信息

• [EN] PHARMACEUTICAL FORMULATIONS FOR THE DELIVERY OF DRUGS HAVING LOW AQUEOUS SOLUBILITY<br/>[FR] FORMULATIONS PHARMACEUTIQUES POUR L'ADMINISTRATION DE MEDICAMENTS AYANT UNE FAIBLE SOLUBILITE AQUEUSE
  申请人：IMARX THERAPEUTICS INC

  公开号：WO2001049268A1

  公开（公告）日：2001-07-12

  Pharmaceutical formulations are provided that increase the systemic bioavailability of a drug that has low aqueous solubility. The drug is physically entrapped by a spatially stabilized matrix of a hydrophilic polymer, but is not covalently bound thereto. Phospholipid moieties are optionally conjugated to the hydrophilic polymer, and free phospholipids, stabilizing agents and/or other excipients may be incorporated into the formulations as well. Therapeutic methods are also provided, wherein a formulation of the invention is administered to a patient to treat a condition, disorder or disease that is responsive to a particular drug. Generally, administration is oral or parenteral.

  提供了一种制药配方，该配方可以增加水溶性低的药物的系统生物利用度。该药物被一个亲水性聚合物的空间稳定的基质物理捕获，但并未与之共价结合。磷脂酰基团可以选择性地与亲水性聚合物结合，而自由磷脂、稳定剂和/或其他辅料也可以被纳入到配方中。还提供了治疗方法，其中将发明的配方用于治疗对特定药物有反应的病症、疾病或疾病。一般来说，给药是口服或注射。
• Novel methods of imaging and treatment with targeted compositions
  申请人：——

  公开号：US20030157025A1

  公开（公告）日：2003-08-21

  Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

  新型超声波方法包括向患者施加含有脂质、蛋白质或聚合物的气囊组成的有针对性的气囊组合物，该气囊包含一种气体，并与一个靶向配体结合，然后使用超声波扫描患者。扫描可能包括将患者暴露于第一种超声波能量，然后使用第二种超声波能量对患者进行询问。靶向配体首选靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该方法可用于检测血栓、旧血栓或回声增强、低浓度气囊和靶向组织、细胞或受体的气囊。
• Novel targeted compositions for diagnostic and therapeutic use
  申请人：——

  公开号：US20020159951A1

  公开（公告）日：2002-10-31

  Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic polymer, and T comprises a targeting ligand which targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The compositions can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

  这是一种可用于诊断和治疗的新型靶向组合物。该组合物可能包含脂质、蛋白质或聚合物气体充填的囊泡，进一步包括一般式为L-P-T的新化合物，其中L包括疏水化合物，P包括亲水性聚合物，T包括靶向配体，可靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该组合物可与诊断成像技术（如超声）以及治疗应用（如治疗性超声）结合使用。
• Apparatus and method for initiating chemical reactions and for the targeted delivery of drugs or other agents
  申请人：Dornier Medtech System GmbH

  公开号：EP1319423A2

  公开（公告）日：2003-06-18

  The present invention is directed to an apparatus and a method for targeted activation or deactivation of chemical reactions, comprising initiation means for initiating cavitation inside at least one medium, wherein the initiation means are adapted to generate photons by means of controlled cavitation for the activation or deactivation of chemical reactions within the at least one medium.

  本发明涉及一种用于有针对性地激活或停用化学反应的装置和方法，该装置包括用于在至少一种介质内引发空化的引发装置，其中引发装置适于通过受控空化产生光子，以激活或停用至少一种介质内的化学反应。
• Improved methods for diagnostic imaging using a contrast agent and a vasodilator
  申请人：IMARX PHARMACEUTICAL CORP.

  公开号：EP1323434A2

  公开（公告）日：2003-07-02

  A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

  现已开发出一种提供病人内部区域图像的方法。该方法通过在成像过程中增强组织和血液之间的对比度来减少成像伪影。该方法包括给患者注射造影剂和肾血管扩张剂，并对该区域进行超声成像。使用该方法可诊断肾脏疾病，包括肾动脉狭窄。