2-chloro-4,6-di-n-propoxy-1,3,5-triazine | 107392-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-chloro-4,6-di-n-propoxy-1,3,5-triazine
• 英文别名: 2-chloro-4,6-dipropoxy-1,3,5-triazine
• CAS: 107392-88-1
• 化学式: C₉H₁₄ClN₃O₂
• 分子量: 231.682
• InChiKey: XUPBSOXSFSWYIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-chloro-4,6-di-n-propoxy-1,3,5-triazine 、 4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride 生成 S-ethyl 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)-phenyl]-2-(4,6-propyloxy-1,3,5-triazin-2-ylamino)propionate
  参考文献：
  名称：

  Phenylalanine derivatives

  摘要：

  公式（1）的苯丙氨酸衍生物如下所述： 其中： Ar1是芳香族或杂环芳基； L1是连接原子或基团； R是羧酸或其衍生物； Ar2是可选择取代的芳香族或杂环芳基； 以及它们的盐、溶剂合物、水合物和N-氧化物。 这些化合物能够抑制α4整合素与其配体的结合，并可用于预防和治疗免疫或炎症性疾病。

  公开号：

  US06348463B1

文献信息

• Heteroaryl-beta-alanine derivatives as alpha 4 integrin inhibitors
  申请人：——

  公开号：US20020086882A1

  公开（公告）日：2002-07-04

  Disclosed are a series of heteroaryl-&bgr;-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.

  揭示了一系列杂环芳基-β-丙氨酸衍生物，包含它们的组合物，其制备方法以及在医学中的应用。
• Method for preserving quaternary ammonium salt
  申请人：——

  公开号：US20030153785A1

  公开（公告）日：2003-08-14

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性提高的季铵盐的方法。
• Phenylalanine derivatives as alpha 4 integrin inhibitors
  申请人：——

  公开号：US20020055509A1

  公开（公告）日：2002-05-09

  Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.

  本发明涉及一系列苯丙氨酸衍生物，涉及含有它们的组合物，涉及它们的制备过程以及它们在医学中的使用。
• PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND CONDENSING AGENT COMPRISING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1085000A1

  公开（公告）日：2001-03-21

  A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to conduct the condensation reaction of the carboxylic acid compound with the compound having a nucleophilic functional group; and a condensing agent comprising the quaternary ammonium salt. By the process, the condensation reaction can be conducted under mild conditions and a carboxylic acid derivative, especially an amide or ester compound, can be obtained in high yield.

  一种生产羧酸衍生物的工艺，其特征在于将分子中含有特定三嗪环的季铵盐、羧酸化合物和具有亲核官能团的化合物混合，以进行羧酸化合物与具有亲核官能团的化合物的缩合反应；以及由季铵盐组成的缩合剂。通过该工艺，可在温和条件下进行缩合反应，并以高产率获得羧酸衍生物，特别是酰胺或酯类化合物。
• METHOD FOR MANUFACTURING POLYROTAXANE
  申请人：Sumitomo Seika Chemicals Co., Ltd.

  公开号：EP2899221A1

  公开（公告）日：2015-07-29

  The present invention aims to provide a method for producing a polyrotaxane which enables industrially advantageous production of a polyrotaxane with a high inclusion rate. The present invention relates to a method for producing a polyrotaxane that includes a cyclodextrin; a compound having a repeating structural unit represented by the following formula (1), and threading through a cavity of the cyclodextrin in a skewered manner to be included in the cyclodextrin; and capping groups individually placed at each end of a molecule of the compound having a repeating structural unit represented by the formula (1) to prevent the cyclodextrin from separating, the method comprising: a step 1 of mixing the compound having a repeating structural unit represented by the formula (1) and the cyclodextrin in an aqueous medium to prepare an aqueous dispersion of pseudopolyrotaxan particles in which the compound having a repeating structural unit represented by the formula (1) is included in a cavity of a cyclodextrin molecule in a skewered manner; and a step 2 of mixing a triazine compound represented by the formula (2), a compound having at least one tertiary amino group, the aqueous dispersion of pseudopolyrotaxane particles prepared in the step 1, and a capping agent to introduce capping groups individually at each end of a molecule of the compound having a repeating structural unit represented by the formula (1) in the pseudopolyrotaxane particles, wherein, in the formula (2), R1 and R2 are each independently a C1-C4 alkyl group or a C6-C8 aryl group, and X represents a halogen atom.

  本发明旨在提供一种生产聚游离基聚氧乙烯醚的方法，该方法能够以工业优势生产出具有高包合率的聚游离基聚氧乙烯醚。 本发明涉及一种生产聚龙沙烷的方法，该方法包括环糊精；具有下式（1）所代表的重复结构单元的化合物，并以串联的方式穿过环糊精的空腔以包含在环糊精中；以及单独置于具有下式（1）所代表的重复结构单元的化合物分子两端的封端基团，以防止环糊精分离，该方法包括：步骤 1 在水性介质中混合具有式（1）所代表的重复结构单元的化合物和环糊精，以制备假多聚糖颗粒的水性分散液，其中具有式（1）所代表的重复结构单元的化合物以串联方式包含在环糊精分子的空腔中；步骤 2：将式（2）代表的三嗪化合物、具有至少一个叔氨基的化合物、步骤 1 中制备的假多聚氧乙烯醚颗粒水分散液和封端剂混合，以便在假多聚氧乙烯醚颗粒中具有式（1）代表的重复结构单元的化合物分子的两端分别引入封端基团、 其中，在式 (2) 中，R1 和 R2 各自独立地为 C1-C4 烷基或 C6-C8 芳基，X 代表卤原子。