2-(1-homopiperidyl) ethylamine dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 2-(1-homopiperidyl) ethylamine dihydrochloride
• 英文别名: 2-(Azepan-1-YL)ethanamine hydrochloride；2-(azepan-1-yl)ethanamine;hydrochloride
• 化学式: C₈H₁₈N₂*2ClH
• 分子量: 215.166
• InChiKey: COHBNBXVGDIZGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-bromo-8-hydroxypsoralen 、 2-(1-homopiperidyl) ethylamine dihydrochloride 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以95.5%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and biological evaluation of fluorescent biphenyl–furocoumarin derivatives

  摘要：

  A series of new biphenyl furocoumarin derivatives were synthesized via Suzuki Miyaura reaction as a critical step. The structures were characterized by NMR, IR and HRMS. All the derivatives presented vasodilatory activity in different degree, especially 6b. Photoelectric properties of all derivatives were investigated by fluorescence, including the variation in different solvents and various pH of 6b. All the ground state molecular geometries from 6a-6j are fully optimized by Density Functional Theory (DFT) on gas phase, which was in accordance with the fluorescence detection. The results suggested cornpounds with biphenyl furocoumarin skeleton would serve as promising vasodilatory candidates as well as fluorescent indicators. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2014.07.011
• 作为产物：
  描述：

  N-(t-butoxycarbonyl)-2-(1-homopiperidyl) ethylamine 在 盐酸 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 反应 0.25h， 生成 2-(1-homopiperidyl) ethylamine dihydrochloride
  参考文献：
  名称：

  EP1172359

  摘要：

  公开号：

文献信息

• NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS
  申请人：Arigon Jérome

  公开号：US20120053170A1

  公开（公告）日：2012-03-01

  The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of the intermediate products.

  本发明涉及式（I）的烟酰胺衍生物，含有该衍生物的组合物，以及其作为抗癌药物的治疗用途。该发明还涉及制备该化合物的方法，以及一些中间产物。
• CEPHALOSPORIN HAVING CATECHOL GROUP
  申请人：Shionogi & Co., Ltd.

  公开号：EP2341053B1

  公开（公告）日：2016-01-13
• EP1172359
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis, characterization and biological evaluation of fluorescent biphenyl–furocoumarin derivatives
  作者：Huaizhen He、Cheng Wang、Tao Wang、Nan Zhou、Zhenyi Wen、Sicen Wang、Langchong He

  DOI：10.1016/j.dyepig.2014.07.011

  日期：2015.2

  A series of new biphenyl furocoumarin derivatives were synthesized via Suzuki Miyaura reaction as a critical step. The structures were characterized by NMR, IR and HRMS. All the derivatives presented vasodilatory activity in different degree, especially 6b. Photoelectric properties of all derivatives were investigated by fluorescence, including the variation in different solvents and various pH of 6b. All the ground state molecular geometries from 6a-6j are fully optimized by Density Functional Theory (DFT) on gas phase, which was in accordance with the fluorescence detection. The results suggested cornpounds with biphenyl furocoumarin skeleton would serve as promising vasodilatory candidates as well as fluorescent indicators. (C) 2014 Elsevier Ltd. All rights reserved.